| http://purl.uniprot.org/citations/25339671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25339671 | http://www.w3.org/2000/01/rdf-schema#comment | "Reductions in C4 levels may predispose individuals to infection with encapsulated bacteria as well as autoimmunity. In this study, we examined the role C4 has in protection against Streptococcus pneumoniae-induced autoimmunity. Mild respiratory infection with serotype 19F pneumococci selectively induced systemic anti-dsDNA IgA production in naive C4(-/-) mice, but not in C3(-/-) or wild-type mice. Systemic challenge with virulent serotype 3 pneumococci also induced anti-dsDNA IgA production in immune C4(-/-) mice. Remarkably, pneumococcal polysaccharide (PPS) vaccination alone induced C4(-/-) mice to produce increased anti-dsDNA IgA levels that were maintained in some mice for months. These effects were most pronounced in female C4(-/-) mice. Importantly, immunization-induced increases in anti-dsDNA IgA levels were strongly associated with increased IgA deposition in kidneys. Cross-reactivity between pneumococcal Ags and dsDNA played a partial role in the induction of anti-dsDNA IgA, but a major role for PPS-associated TLR2 agonists was also revealed. Administration of the TLR2/4 antagonist, OxPAPC, at the time of PPS immunization completely blocked the production of anti-dsDNA IgA in C4(-/-) mice without suppressing PPS-specific Ab production. The TLR2 agonist, Pam3CSK4, similarly induced anti-dsDNA IgA production in C4(-/-) mice, which OxPAPC also prevented. LPS, a TLR4 agonist, had no effect. Pam3CSK4, but not LPS, also induced dsDNA-specific IgA production by C4(-/-) splenic IgA(+) B cells in vitro, indicating that TLR2 agonists can stimulate autoantibody production via B cell-intrinsic mechanisms. Collectively, our results show an important role for C4 in suppressing autoantibody production elicited by cross-reactive Ags and TLR2 agonists associated with S. pneumoniae."xsd:string |
| http://purl.uniprot.org/citations/25339671 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1401462"xsd:string |
| http://purl.uniprot.org/citations/25339671 | http://purl.uniprot.org/core/author | "Haas K.M."xsd:string |
| http://purl.uniprot.org/citations/25339671 | http://purl.uniprot.org/core/author | "Yammani R.D."xsd:string |
| http://purl.uniprot.org/citations/25339671 | http://purl.uniprot.org/core/author | "Jennings R.N."xsd:string |
| http://purl.uniprot.org/citations/25339671 | http://purl.uniprot.org/core/author | "Leyva M.A."xsd:string |
| http://purl.uniprot.org/citations/25339671 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25339671 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25339671 | http://purl.uniprot.org/core/pages | "5434-5443"xsd:string |
| http://purl.uniprot.org/citations/25339671 | http://purl.uniprot.org/core/title | "C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production."xsd:string |
| http://purl.uniprot.org/citations/25339671 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/25339671 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25339671 |
| http://purl.uniprot.org/citations/25339671 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25339671 |
| http://purl.uniprot.org/uniprot/#_B2RXW7-mappedCitation-25339671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25339671 |
| http://purl.uniprot.org/uniprot/#_B2RWX2-mappedCitation-25339671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25339671 |
| http://purl.uniprot.org/uniprot/#_B0G0Y3-mappedCitation-25339671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25339671 |
| http://purl.uniprot.org/uniprot/#_P01029-mappedCitation-25339671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25339671 |
| http://purl.uniprot.org/uniprot/#_Q3TYN1-mappedCitation-25339671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25339671 |
| http://purl.uniprot.org/uniprot/#_Q3TAT4-mappedCitation-25339671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25339671 |
| http://purl.uniprot.org/uniprot/#_Q9QUF9-mappedCitation-25339671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25339671 |
| http://purl.uniprot.org/uniprot/#_Q9QWR4-mappedCitation-25339671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25339671 |
| http://purl.uniprot.org/uniprot/B0G0Y3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25339671 |
| http://purl.uniprot.org/uniprot/Q9QWR4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25339671 |
| http://purl.uniprot.org/uniprot/Q3TAT4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25339671 |