| http://purl.uniprot.org/citations/25344755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25344755 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin C was cloned as a growth-promoting G1 cyclin, and was also shown to regulate gene transcription. Here we report that in vivo cyclin C acts as a haploinsufficient tumour suppressor, by controlling Notch1 oncogene levels. Cyclin C activates an 'orphan' CDK19 kinase, as well as CDK8 and CDK3. These cyclin-C-CDK complexes phosphorylate the Notch1 intracellular domain (ICN1) and promote ICN1 degradation. Genetic ablation of cyclin C blocks ICN1 phosphorylation in vivo, thereby elevating ICN1 levels in cyclin-C-knockout mice. Cyclin C ablation or heterozygosity collaborates with other oncogenic lesions and accelerates development of T-cell acute lymphoblastic leukaemia (T-ALL). Furthermore, the cyclin C encoding gene CCNC is heterozygously deleted in a significant fraction of human T-ALLs, and these tumours express reduced cyclin C levels. We also describe point mutations in human T-ALL that render cyclin-C-CDK unable to phosphorylate ICN1. Hence, tumour cells may develop different strategies to evade inhibition by cyclin C."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3046"xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Geng Y."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Inuzuka H."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Wei W."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Gutierrez A."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "King B."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Look A.T."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Roy M."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Ordureau A."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Zhao J.J."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Meyer C.A."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Ke N."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Fassl A."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Aster J.C."xsd:string |
| http://purl.uniprot.org/citations/25344755 | http://purl.uniprot.org/core/author | "Shaik S."xsd:string |