| http://purl.uniprot.org/citations/25346274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25346274 | http://www.w3.org/2000/01/rdf-schema#comment | "Increasing evidence suggests that HLA-DRB1 alleles reduce or increase the risk of developing ulcerative colitis-associated colorectal carcinoma (CRC) tumors. However, the role of HLA-DRB1 locus on the susceptibility to develop CRC tumor, in the absence of a history of inflammatory bowel diseases (IBDs), is unclear. The aim of our study was to determine whether HLA-DRB1 alleles are associated with IBD-independent CRC tumor. HLA-DRB1 allele polymorphisms were identified by sequence-based typing method in 53 CRC patients and 57 sex- and age-matched healthy Caucasian controls. Pearson's chi-squared analysis with Yate's correction or Fisher's exact test with Bonferroni's correction, as appropriate, were used to compare the allele frequency (AF) differences of HLA-DRB1 in patients and controls. A total of 29 HLA-DRB1 alleles were recognized. A detailed study of these alleles allowed to identify DRB1*13:01 and DRB1*11:01 alleles that were significantly associated with an increased and reduced risk to develop CRC tumor, respectively. AF of DRB1*13:01, in CRC patients, was significantly higher than that of healthy controls, even following Bonferroni's correction (p = 0.029). In contrast, the presence of the DRB1*11:01 allele was negatively associated with CRC tumor as evidenced by the significantly lower AF in CRC patients than that of healthy controls (p = 0.005). However, following Bonferroni's correction, the AF of DRB*11:01 lost its statistical significance. These results suggest that HLA-DRB1*13:01 allele could be a potential marker for predicting genetic susceptibility to CRC tumor. In contrast, the protective role of DRB1*11:01 remains unclear."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.29285"xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Rossi P."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Lauro D."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Coppola A."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Aureli A."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Canossi A."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Del Beato T."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Papola F."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Orlandi A."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Sconocchia G."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Buonomo O."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Lanzilli G."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Sileri P."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Franceschilli L."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "De Sanctis F."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Arriga R."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/author | "Caratelli S."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/pages | "2464-2468"xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/title | "HLA-DRB1*13:01 allele in the genetic susceptibility to colorectal carcinoma."xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/25346274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25346274 |