| http://purl.uniprot.org/citations/25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25355043 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis. Here, we demonstrate that the deubiquitinase Cezanne regulates HIF-1α homeostasis. Loss of Cezanne decreases HIF-1α target gene expression due to a reduction in HIF-1α protein levels. Surprisingly, although the Cezanne-regulated degradation of HIF-1α depends on the tumour suppressor pVHL, hydroxylase and proteasome activity are dispensable. Our data suggest that Cezanne is essential for HIF-1α protein stability and that loss of Cezanne stimulates HIF-1α degradation via proteasome-independent routes, possibly through chaperone-mediated autophagy."xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.201438850"xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://purl.uniprot.org/core/author | "Komander D."xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://purl.uniprot.org/core/author | "Rocha S."xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://purl.uniprot.org/core/author | "Bremm A."xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://purl.uniprot.org/core/author | "Moniz S."xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://purl.uniprot.org/core/author | "Mader J."xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25355043 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://purl.uniprot.org/core/pages | "1268-1277"xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://purl.uniprot.org/core/title | "Cezanne (OTUD7B) regulates HIF-1alpha homeostasis in a proteasome-independent manner."xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/25355043 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25355043 |
| http://purl.uniprot.org/citations/25355043 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25355043 |
| http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25355043 |
| http://purl.uniprot.org/uniprot/#_D3YYZ8-mappedCitation-25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25355043 |
| http://purl.uniprot.org/uniprot/#_D3Z210-mappedCitation-25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25355043 |
| http://purl.uniprot.org/uniprot/#_B2R617-mappedCitation-25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25355043 |
| http://purl.uniprot.org/uniprot/#_B2RUR8-mappedCitation-25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25355043 |
| http://purl.uniprot.org/uniprot/#_A8MYV6-mappedCitation-25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25355043 |
| http://purl.uniprot.org/uniprot/#_B4E2K5-mappedCitation-25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25355043 |
| http://purl.uniprot.org/uniprot/#_B4E2U7-mappedCitation-25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25355043 |
| http://purl.uniprot.org/uniprot/#_B4DL76-mappedCitation-25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25355043 |
| http://purl.uniprot.org/uniprot/#_B4DS34-mappedCitation-25355043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25355043 |