| http://purl.uniprot.org/citations/25355318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25355318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25355318 | http://www.w3.org/2000/01/rdf-schema#comment | "As a large double-stranded DNA virus, herpes simplex virus type 1 (HSV-1) assembles capsids in the nucleus where the viral particles exit by budding through the inner nuclear membrane. Although a number of viral and host proteins are involved, the machinery of viral egress is not well understood. In a search for host interacting proteins of ICP34.5, which is a virulence factor of HSV-1, we identified a cellular protein, p32 (gC1qR/HABP1), by mass spectrophotometer analysis. When expressed, ICP34.5 associated with p32 in mammalian cells. Upon HSV-1 infection, p32 was recruited to the inner nuclear membrane by ICP34.5, which paralleled the phosphorylation and rearrangement of nuclear lamina. Knockdown of p32 in HSV-1-infected cells significantly reduced the production of cell-free viruses, suggesting that p32 is a mediator of HSV-1 nuclear egress. These observations suggest that the interaction between HSV-1 ICP34.5 and p32 leads to the disintegration of nuclear lamina and facilitates the nuclear egress of HSV-1 particles."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.603845"xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.603845"xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "He B."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "He B."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Dong S."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Dong S."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Pan S."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Pan S."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Ru Y."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Ru Y."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Zhou C."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Zhou C."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/25355318 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |