| http://purl.uniprot.org/citations/25358791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25358791 | http://www.w3.org/2000/01/rdf-schema#comment | "Lung development-associated diseases are major causes of morbidity and lethality in preterm infants and children. Access to the lung progenitor/stem cell populations controlling pulmonary development during embryogenesis and early postnatal years is essential to understand the molecular basis of such diseases. Using a Nkx2-1(mCherry) reporter mouse, we have identified and captured Nkx2-1-expressing lung progenitor cells from the proximal lung epithelium during fetal development. These cells formed clonal spheres in semisolid culture that could be maintained in vitro and demonstrated self-renewal and expansion capabilities over multiple passages. In-vitro-derived Nkx2-1-expressing clonal spheres differentiated into a polarized epithelium comprised of multiple cell lineages, including basal and secretory cells, that could repopulate decellularized lung scaffolds. Nkx2-1 expression thus defines a fetal lung epithelial progenitor cell population that can be used as a model system to study pulmonary development and associated pediatric diseases."xsd:string |
| http://purl.uniprot.org/citations/25358791 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stemcr.2014.07.010"xsd:string |
| http://purl.uniprot.org/citations/25358791 | http://purl.uniprot.org/core/author | "Ackerley C."xsd:string |
| http://purl.uniprot.org/citations/25358791 | http://purl.uniprot.org/core/author | "Post M."xsd:string |
| http://purl.uniprot.org/citations/25358791 | http://purl.uniprot.org/core/author | "Rossant J."xsd:string |
| http://purl.uniprot.org/citations/25358791 | http://purl.uniprot.org/core/author | "Bilodeau M."xsd:string |
| http://purl.uniprot.org/citations/25358791 | http://purl.uniprot.org/core/author | "Shojaie S."xsd:string |
| http://purl.uniprot.org/citations/25358791 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25358791 | http://purl.uniprot.org/core/name | "Stem Cell Reports"xsd:string |
| http://purl.uniprot.org/citations/25358791 | http://purl.uniprot.org/core/pages | "634-649"xsd:string |
| http://purl.uniprot.org/citations/25358791 | http://purl.uniprot.org/core/title | "Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential."xsd:string |
| http://purl.uniprot.org/citations/25358791 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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