| http://purl.uniprot.org/citations/25361078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25361078 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspases and the cytotoxic lymphocyte protease granzyme B (GB) induce reactive oxygen species (ROS) formation, loss of transmembrane potential and mitochondrial outer membrane permeabilization (MOMP). Whether ROS are required for GB-mediated apoptosis and how GB induces ROS is unclear. Here, we found that GB induces cell death in an ROS-dependent manner, independently of caspases and MOMP. GB triggers ROS increase in target cell by directly attacking the mitochondria to cleave NDUFV1, NDUFS1 and NDUFS2 subunits of the NADH: ubiquinone oxidoreductase complex I inside mitochondria. This leads to mitocentric ROS production, loss of complex I and III activity, disorganization of the respiratory chain, impaired mitochondrial respiration and loss of the mitochondrial cristae junctions. Furthermore, we have also found that GB-induced mitocentric ROS are necessary for optimal apoptogenic factor release, rapid DNA fragmentation and lysosomal rupture. Interestingly, scavenging the ROS delays and reduces many of the features of GB-induced death. Consequently, GB-induced ROS significantly promote apoptosis."xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2014.180"xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/author | "Thiery J."xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/author | "Lieberman J."xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/author | "Martinvalet D."xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/author | "Walch M."xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/author | "Kasahara A."xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/author | "Jacquemin G."xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/author | "Bassoy E.Y."xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/author | "Margiotta D."xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/pages | "862-874"xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/title | "Granzyme B-induced mitochondrial ROS are required for apoptosis."xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/25361078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25361078 |
| http://purl.uniprot.org/citations/25361078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25361078 |
| http://purl.uniprot.org/uniprot/#_P10144-mappedCitation-25361078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25361078 |
| http://purl.uniprot.org/uniprot/#_J3KQ52-mappedCitation-25361078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25361078 |
| http://purl.uniprot.org/uniprot/#_Q67BC3-mappedCitation-25361078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25361078 |
| http://purl.uniprot.org/uniprot/#_Q6XGZ2-mappedCitation-25361078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25361078 |
| http://purl.uniprot.org/uniprot/#_Q6XGZ3-mappedCitation-25361078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25361078 |
| http://purl.uniprot.org/uniprot/#_Q6XGZ4-mappedCitation-25361078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25361078 |
| http://purl.uniprot.org/uniprot/P10144 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25361078 |