| http://purl.uniprot.org/citations/25361773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25361773 | http://www.w3.org/2000/01/rdf-schema#comment | "The epithelial-mesenchymal transition (EMT) of tubular epithelial cells to myofibroblast-like cells plays a substantial role in renal tubulointerstitial fibrosis, which is a common pathological character of end-stage renal disease (ESRD). Fibroblast growth factor-2 (FGF-2) triggers EMT in tubular epithelial cells and increases Bcl-2-associated athanogene 3 (BAG3) expression in neural progenitor and neuroblastoma cells. In addition, a novel role of regulation of EMT has been ascribed to BAG3 recently. These previous reports urged us to study the potential involvement of BAG3 in EMT triggered by FGF-2 in renal tubular epithelial cells. The current study found that FGF-2 induced EMT, simultaneously increased BAG3 expression in human kidney 2 (HK2) cells. Although FGF-2 induced EMT in nontransfected or scramble short hairpin RNA (shRNA) transfected HK2 cells, it was ineffective in BAG3-silenced cells, indicating a favorable role of BAG3 in EMT of tubular cells induced by FGF-2. Knockdown of BAG3 also significantly suppressed motion and invasion of HK2 cells mediated by FGF-2. Furthermore, we confirmed that BAG3 was upregulated in kidney of unilateral ureteral obstruction (UUO) rats, a well-established renal fibrosis model, in which EMT is supposed to exert a substantial influence on renal fibrosis. Importantly, upregulation of BAG3 was limited to tubular epithelial cells. Results of the current study identify BAG3 as a potential player in EMT of tubular epithelial cells, as well as renal fibrosis."xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.org/dc/terms/identifier | "doi:10.1177/1535370214558023"xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/author | "Du F."xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/author | "Zhang H.Y."xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/author | "Wang H.Q."xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/author | "Li D.T."xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/author | "Du Z.X."xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/name | "Exp Biol Med (Maywood)"xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/pages | "566-575"xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/title | "Implication of Bcl-2-associated athanogene 3 in fibroblast growth factor-2-mediated epithelial-mesenchymal transition in renal epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://purl.uniprot.org/core/volume | "240"xsd:string |
| http://purl.uniprot.org/citations/25361773 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25361773 |
| http://purl.uniprot.org/citations/25361773 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25361773 |
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| http://purl.uniprot.org/uniprot/#_Q53GY1-mappedCitation-25361773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25361773 |
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| http://purl.uniprot.org/uniprot/P09038 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25361773 |