| http://purl.uniprot.org/citations/25361975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25361975 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the promoter region of mu-opioid receptor (MOR) to regulate its transcriptional activity. How hnRNP K contributes to the analgesic effects of morphine, however, is largely unknown. We provide evidence that morphine increases hnRNP K protein expression via MOR activation in rat primary cortical neurons and HEK-293 cells expressing MORs, without increasing mRNA levels. Using the bicistronic reporter assay, we examined whether morphine-mediated accumulation of hnRNP K resulted from translational control. We identified potential internal ribosome entry site elements located in the 5' untranslated regions of hnRNP K transcripts that were regulated by morphine. This finding suggests that internal translation contributes to the morphine-induced accumulation of hnRNP K protein in regions of the central nervous system correlated with nociceptive and antinociceptive modulatory systems in mice. Finally, we found that down-regulation of hnRNP K mediated by siRNA attenuated morphine-induced hyperpolarization of membrane potential in AtT20 cells. Silencing hnRNP K expression in the spinal cord increased nociceptive sensitivity in wild-type mice, but not in MOR-knockout mice. Thus, our findings identify the role of translational control of hnRNP K in morphine-induced analgesia through activation of MOR."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gku1016"xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Lin Y.C."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Chen S.C."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Yeh S.H."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Chang H.F."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Chao Y.S."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Lee P.T."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Loh H.H."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Chuang J.Y."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Su T.P."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Law P.Y."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Ou L.C."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/author | "Chao P.K."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/pages | "13012-13025"xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/title | "Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling."xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/25361975 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25361975 |
| http://purl.uniprot.org/citations/25361975 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25361975 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0Z2-mappedCitation-25361975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25361975 |
| http://purl.uniprot.org/uniprot/#_A0A286YDH1-mappedCitation-25361975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25361975 |
| http://purl.uniprot.org/uniprot/#_A0A286YDM3-mappedCitation-25361975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25361975 |