| http://purl.uniprot.org/citations/25370275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25370275 | http://www.w3.org/2000/01/rdf-schema#comment | "The Sonic hedgehog (Shh) signalling pathway plays important roles during development and in cancer. Here we report a Shh-induced epigenetic switch that cooperates with Gli to control transcription outcomes. Before induction, poised Shh target genes are marked by a bivalent chromatin domain containing a repressive histone H3K27me3 mark and an active H3K4me3 mark. Shh activation induces a local switch of epigenetic cofactors from the H3K27 methyltransferase polycomb repressive complex 2 (PRC2) to an H3K27me3 demethylase Jmjd3/Kdm6b-centred coactivator complex. We also find that non-enzymatic activities of Jmjd3 are important and that Jmjd3 recruits the Set1/MLL H3K4 methyltransferase complexes in a Shh-dependent manner to resolve the bivalent domain. In vivo, changes of the bivalent domain accompanied Shh-activated cerebellar progenitor proliferation. Overall, our results reveal a regulatory mechanism that underlies the activation of Shh target genes and provides insight into the causes of various diseases and cancers exhibiting altered Shh signalling."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms6425"xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Cao M."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Satoh T."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Magnuson T."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Zhan X."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Ge K."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/author | "Shpargel K."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/pages | "5425"xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/title | "An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth."xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25370275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25370275 |
| http://purl.uniprot.org/citations/25370275 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25370275 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-25370275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25370275 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-25370275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25370275 |