| http://purl.uniprot.org/citations/25375034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25375034 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously demonstrated that advanced glycation-end products (AGEs) promote the pathological progression of diabetic nephropathy by decreasing silent information regulator 2-related protein 1 (Sirt1) expression in glomerular mesangial cells (GMCs). Here, we investigated whether AGEs-receptor for AGEs (RAGE) system down-regulated Sirt1 expression through ubiquitin-proteasome pathway and whether Sirt1 ubiquitination affected fibronectin (FN) and TGF-β1, 2 fibrotic indicators in GMCs. Sirt1 was polyubiquitinated and subsequently degraded by proteasome. AGEs increased Sirt1 ubiquitination and proteasome-mediated degradation, shortened Sirt1 half-life, and promoted FN and TGF-β1 expression. Ubiquitin-specific protease 22 (USP22) reduced Sirt1 ubiquitination and degradation and decreased FN and TGF-β1 expression in GMCs under both basal and AGEs-treated conditions. USP22 depletion enhanced Sirt1 degradation and displayed combined effects with AGEs to further promote FN and TGF-β1 expression. RAGE functioned crucial mediating roles in these processes via its C-terminal cytosolic domain. Inhibiting Sirt1 by EX-527 substantially suppressed the down-regulation of FN and TGF-β1 resulting from USP22 overexpression under both normal and AGEs-treated conditions, eventually leading to their up-regulation in GMCs. These results indicated that the AGEs-RAGE system increased the ubiquitination and subsequent proteasome-mediated degradation of Sirt1 by reducing USP22 level, and AGEs-RAGE-USP22-Sirt1 formed a cascade pathway that regulated FN and TGF-β1 level, which participated in the pathological progression of diabetic nephropathy."xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2014-1381"xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/author | "Hao J."xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/author | "Huang J.Y."xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/author | "Liu P.Q."xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/author | "Huang K.P."xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/author | "Huang H.Q."xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/pages | "268-279"xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/title | "AGEs-RAGE system down-regulates Sirt1 through the ubiquitin-proteasome pathway to promote FN and TGF-beta1 expression in male rat glomerular mesangial cells."xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://purl.uniprot.org/core/volume | "156"xsd:string |
| http://purl.uniprot.org/citations/25375034 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25375034 |
| http://purl.uniprot.org/citations/25375034 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25375034 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JZ79-mappedCitation-25375034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25375034 |
| http://purl.uniprot.org/uniprot/#_A0A096P6L8-mappedCitation-25375034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25375034 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A5M1-mappedCitation-25375034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25375034 |
| http://purl.uniprot.org/uniprot/#_A6JKY4-mappedCitation-25375034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25375034 |
| http://purl.uniprot.org/uniprot/#_A6JKY5-mappedCitation-25375034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25375034 |
| http://purl.uniprot.org/uniprot/#_A6KFG4-mappedCitation-25375034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25375034 |
| http://purl.uniprot.org/uniprot/#_A6KFG5-mappedCitation-25375034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25375034 |
| http://purl.uniprot.org/uniprot/#_A6KFG6-mappedCitation-25375034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25375034 |
| http://purl.uniprot.org/uniprot/#_A6KFG7-mappedCitation-25375034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25375034 |