| http://purl.uniprot.org/citations/25381825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25381825 | http://www.w3.org/2000/01/rdf-schema#comment | "Using integrative genomics and functional screening, we identified coiled-coil domain containing 68 (CCDC68) as a novel putative tumor suppressor gene (TSG) in pancreatic ductal adenocarcinoma (PDAC). CCDC68 allelic losses were documented in 48% of primary PDAC patient tumors, 50% of PDAC cell lines and 30% of primary patient derived xenografts. We also discovered a single nucleotide polymorphism (SNP) variant (SNP rs1344011) that leads to exon skipping and generation of an unstable protein isoform CCDC68Δ(69-114) in 31% of PDAC patients. Overexpression of full length CCDC68 (CCDC68(wt)) in PANC-1 and Hs.766T PDAC cell lines lacking CDCC68 expression decreased proliferation and tumorigenicity in scid mice. In contrast, the downregulation of endogenous CCDC68 in MIAPaca-2 cells increased tumor growth rate. These effects were not observed with the deletion-containing isoform, CCDC68Δ(69-114)."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2014.357"xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Lam W.L."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Moffat J."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Lockwood W.W."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Tsao M.S."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Leung L."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Zhu C.Q."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Kaufman E."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Navab R."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Sakashita S."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Radulovich N."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Fedyshyn Y."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Ibrahimov E."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/author | "Thu K.L."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/pages | "4238-4247"xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/title | "Coiled-coil domain containing 68 (CCDC68) demonstrates a tumor-suppressive role in pancreatic ductal adenocarcinoma."xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/25381825 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25381825 |
| http://purl.uniprot.org/citations/25381825 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25381825 |
| http://purl.uniprot.org/uniprot/#_Q9H2F9-mappedCitation-25381825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25381825 |
| http://purl.uniprot.org/uniprot/Q9H2F9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25381825 |