| http://purl.uniprot.org/citations/25383523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25383523 | http://www.w3.org/2000/01/rdf-schema#comment | "Lysosomal degradation of cytoplasmic components by autophagy is essential for cellular survival and homeostasis under nutrient-deprived conditions. Acute regulation of autophagy by nutrient-sensing kinases is well defined, but longer-term transcriptional regulation is relatively unknown. Here we show that the fed-state sensing nuclear receptor farnesoid X receptor (FXR) and the fasting transcriptional activator cAMP response element-binding protein (CREB) coordinately regulate the hepatic autophagy gene network. Pharmacological activation of FXR repressed many autophagy genes and inhibited autophagy even in fasted mice, and feeding-mediated inhibition of macroautophagy was attenuated in FXR-knockout mice. From mouse liver chromatin immunoprecipitation and high-throughput sequencing data, FXR and CREB binding peaks were detected at 178 and 112 genes, respectively, out of 230 autophagy-related genes, and 78 genes showed shared binding, mostly in their promoter regions. CREB promoted autophagic degradation of lipids, or lipophagy, under nutrient-deprived conditions, and FXR inhibited this response. Mechanistically, CREB upregulated autophagy genes, including Atg7, Ulk1 and Tfeb, by recruiting the coactivator CRTC2. After feeding or pharmacological activation, FXR trans-repressed these genes by disrupting the functional CREB-CRTC2 complex. This study identifies the new FXR-CREB axis as a key physiological switch regulating autophagy, resulting in sustained nutrient regulation of autophagy during feeding/fasting cycles."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature13949"xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Kang Y."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Zhong W."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Zhu R."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Kemper B."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Fu T."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Choi S.E."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Yoon G."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Kemper J.K."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/author | "Seok S."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/pages | "108-111"xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/title | "Transcriptional regulation of autophagy by an FXR-CREB axis."xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://purl.uniprot.org/core/volume | "516"xsd:string |
| http://purl.uniprot.org/citations/25383523 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25383523 |
| http://purl.uniprot.org/citations/25383523 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25383523 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI6-mappedCitation-25383523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25383523 |
| http://purl.uniprot.org/uniprot/#_Q62347-mappedCitation-25383523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25383523 |