| http://purl.uniprot.org/citations/25385014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25385014 | http://www.w3.org/2000/01/rdf-schema#comment | "Rab GTPases are key regulators of intracellular membrane traffic acting through their effector molecules. Rabaptin-5 is a Rab5 effector in early endosome fusion and connects Rab5- and Rab4-positive membrane compartments owing to its ability to interact with Rab4 GTPase. Recent studies showed that Rabaptin-5 transcript is subjected to extensive alternative splicing, thus resulting in expression of Rabaptin-5 isoforms mostly bearing short deletions in the polypeptide chain. As interactions of a Rab GTPase with different effectors lead to different responses, functional characterization of Rabaptin-5 isoforms becomes an attractive issue. Indeed, it was shown that Rab GTPase effector properties of Rabaptin-5 and its α and δ isoforms are different. This work focused on another Rabaptin-5 isoform, Rabaptin-5γ. Despite its ability to interact with Rab5, endogenously produced Rabaptin-5γ was absent from early endosomes. Rather, it was found to be tightly associated with trans-Golgi network and partially localized to a Rab4-positive membrane compartment. The revealed intracellular localization of Rabaptin-5γ indicates that it is not involved in Rab5-driven events; rather, it functions in other membrane transport steps. Our study signifies the role of alternative splicing in determination of functional activities of Rab effector molecules."xsd:string |
| http://purl.uniprot.org/citations/25385014 | http://purl.org/dc/terms/identifier | "doi:10.1134/s000629791409003x"xsd:string |
| http://purl.uniprot.org/citations/25385014 | http://purl.uniprot.org/core/author | "Korobko I.V."xsd:string |
| http://purl.uniprot.org/citations/25385014 | http://purl.uniprot.org/core/author | "Kiselev S.L."xsd:string |
| http://purl.uniprot.org/citations/25385014 | http://purl.uniprot.org/core/author | "Korobko E.V."xsd:string |
| http://purl.uniprot.org/citations/25385014 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25385014 | http://purl.uniprot.org/core/name | "Biochemistry (Mosc)"xsd:string |
| http://purl.uniprot.org/citations/25385014 | http://purl.uniprot.org/core/pages | "856-864"xsd:string |
| http://purl.uniprot.org/citations/25385014 | http://purl.uniprot.org/core/title | "Characterization of Rabaptin-5 gamma isoform."xsd:string |
| http://purl.uniprot.org/citations/25385014 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/25385014 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25385014 |
| http://purl.uniprot.org/citations/25385014 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25385014 |
| http://purl.uniprot.org/uniprot/#_O35551-mappedCitation-25385014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25385014 |
| http://purl.uniprot.org/uniprot/#_J3QJV7-mappedCitation-25385014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25385014 |
| http://purl.uniprot.org/uniprot/#_Q3U983-mappedCitation-25385014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25385014 |
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| http://purl.uniprot.org/uniprot/Q3U983 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25385014 |
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| http://purl.uniprot.org/uniprot/J3QJV7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25385014 |