Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/25385317http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25385317http://www.w3.org/2000/01/rdf-schema#comment"

Background

In most research, there were positive associations between the insulin-like growth factor I (IGF-I) status, including IGF-I, insulin-like growth factor binding protein-3 (IGFBP-3), and ratio of IGF-I/IGFBP-3, and risks of breast cancer (BC), which was influenced by many factors, including hormone statuses and ethnicity. Therefore, the alterations of the IGF-I status in Taiwanese women with BC by menopausal statuses and hormone receptors were investigated.

Methods

The levels of IGF-I and IGFBP-3 were determined by the enzyme-labeled chemiluminescent immunometric assay, and the protein expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) on paraffin-embedded sections of tissues with BC were analyzed by the immunohistochemical method.

Results

The ratios of IGF-I/IGFBP-3 were significantly higher in the women with BC than those in the controls, but not of the levels of IGF-I and IGFBP-3; furthermore, the significantly higher ratios were found only in the postmenopausal status. In addition, there was no significant difference between the IGF-I status and ER and PR statuses, and HER2 expression, respectively, in the women with BC.

Conclusions

The ratios of IGF-I/IGFBP-3 were increased in postmenopausal Taiwanese women with BC, irrespective of their ages, ER and PR statuses, and HER2 expression."xsd:string
http://purl.uniprot.org/citations/25385317http://purl.org/dc/terms/identifier"doi:10.1002/jcla.21815"xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/author"Lee S.C."xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/author"Tsai S.M."xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/author"Wu S.H."xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/author"Tsai L.Y."xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/author"Hou M.F."xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/author"Tsai J.M."xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/author"Hou L.A."xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/author"Tien L.Y."xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/name"J Clin Lab Anal"xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/pages"58-64"xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/title"Increased Igf-I/Igfbp-3 Ratios in Postmenopausal Taiwanese with Breast Cancer, Irrespective of Er and Pr Statuses and Her2 Expression in a Case-Control Study."xsd:string
http://purl.uniprot.org/citations/25385317http://purl.uniprot.org/core/volume"30"xsd:string
http://purl.uniprot.org/citations/25385317http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25385317
http://purl.uniprot.org/citations/25385317http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25385317
http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-25385317http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25385317
http://purl.uniprot.org/uniprot/#_A0A125SXW1-mappedCitation-25385317http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25385317
http://purl.uniprot.org/uniprot/#_Q14268-mappedCitation-25385317http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25385317
http://purl.uniprot.org/uniprot/#_A0A1U9WZ84-mappedCitation-25385317http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25385317
http://purl.uniprot.org/uniprot/#_A0A125SXV8-mappedCitation-25385317http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25385317
http://purl.uniprot.org/uniprot/#_A0A125SXV9-mappedCitation-25385317http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25385317
http://purl.uniprot.org/uniprot/#_A0A125SXW2-mappedCitation-25385317http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25385317
▶