| http://purl.uniprot.org/citations/25389272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25389272 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucleic acid-dependent ATPases are involved in nearly all aspects of DNA and RNA metabolism. Previous studies have described a number of mitochondrial helicases. However, double-stranded DNA-dependent ATPases, including translocases or enzymes remodeling DNA-protein complexes, have not been identified in mitochondria of the yeast Saccharomyces cerevisae. Here, we demonstrate that Irc3p is a mitochondrial double-stranded DNA-dependent ATPase of the Superfamily II. In contrast to the other mitochondrial Superfamily II enzymes Mss116p, Suv3p and Mrh4p, which are RNA helicases, Irc3p has a direct role in mitochondrial DNA (mtDNA) maintenance. Specific Irc3p-dependent mtDNA metabolic intermediates can be detected, including high levels of double-stranded DNA breaks that accumulate in irc3Δ mutants. irc3Δ-related topology changes in rho-mtDNA can be reversed by the deletion of mitochondrial RNA polymerase RPO41, suggesting that Irc3p counterbalances adverse effects of transcription on mitochondrial genome stability."xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gku1148"xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://purl.uniprot.org/core/author | "Hou Y."xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://purl.uniprot.org/core/author | "Sedman J."xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://purl.uniprot.org/core/author | "Sedman T."xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://purl.uniprot.org/core/author | "Gaidutsik I."xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://purl.uniprot.org/core/author | "Villemson K."xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25389272 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://purl.uniprot.org/core/pages | "13214-13227"xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://purl.uniprot.org/core/title | "Double-stranded DNA-dependent ATPase Irc3p is directly involved in mitochondrial genome maintenance."xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/25389272 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25389272 |
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| http://purl.uniprot.org/uniprot/Q06683#attribution-EF6B79542A21ABC540476844DAE5E8EA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25389272 |
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