| http://purl.uniprot.org/citations/25394790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25394790 | http://www.w3.org/2000/01/rdf-schema#comment | "In certain human cancers, the expression of critical oncogenes is driven from large regulatory elements, called super-enhancers, that recruit much of the cell's transcriptional apparatus and are defined by extensive acetylation of histone H3 lysine 27 (H3K27ac). In a subset of T-cell acute lymphoblastic leukemia (T-ALL) cases, we found that heterozygous somatic mutations are acquired that introduce binding motifs for the MYB transcription factor in a precise noncoding site, which creates a super-enhancer upstream of the TAL1 oncogene. MYB binds to this new site and recruits its H3K27 acetylase-binding partner CBP, as well as core components of a major leukemogenic transcriptional complex that contains RUNX1, GATA-3, and TAL1 itself. Additionally, most endogenous super-enhancers found in T-ALL cells are occupied by MYB and CBP, which suggests a general role for MYB in super-enhancer initiation. Thus, this study identifies a genetic mechanism responsible for the generation of oncogenic super-enhancers in malignant cells."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1259037"xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Young R.A."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Gutierrez A."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Berezovskaya A."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Look A.T."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Sanda T."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Hunger S.P."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Etchin J."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Loh M.L."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Sallan S.E."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Silverman L.B."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Lawton L."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Anders L."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Mansour M.R."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Durbin A.D."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/author | "Abraham B.J."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/pages | "1373-1377"xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/title | "Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element."xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://purl.uniprot.org/core/volume | "346"xsd:string |
| http://purl.uniprot.org/citations/25394790 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25394790 |
| http://purl.uniprot.org/citations/25394790 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25394790 |