| http://purl.uniprot.org/citations/25400809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25400809 | http://www.w3.org/2000/01/rdf-schema#comment | "Cutaneous squamous cell carcinoma (cSCC), the second most common form of human cancer, is an epithelial skin tumor, which can result in metastasis with lethal consequences accounting for about 20% of all skin cancer-related deaths. The metastasis is the main reason for cSCC-related deaths with an overall 5-year survival rate < 30% in cases that spread systemically. The role of miRNAs has been involved in SCC of different origins. Recent data have revealed that the expression of miRNA-199a was changed in many human cancers. In this study, we found that miR-199a was significantly decreased in cSCC tissues, which had an inverse relationship with CD44. MiR-199a specifically regulated the expression of CD44 at mRNA and protein levels, and the interaction between CD44 and Ezrin in cSCC cells. Moreover, the suppressive role of miR-199a in cell migration in cSCC cells was also associated with the activity of MMP2 and MMP9. Taken together, our data indicated that increased expression of endogenous mature miR-199a might prevent the growth and migration of human cSCC via decreasing the expression of CD44 and regulating the interaction between CD44 and Ezrin, which may provide a potentially important therapeutic target for human cSCC."xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/author | "Wang S.H."xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/author | "Cao K."xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/author | "He Q.Y."xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/author | "Yin Z.Q."xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/author | "Luo C.Q."xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/author | "Zhou J.D."xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/name | "Int J Clin Exp Pathol"xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/pages | "7131-7141"xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/title | "MiR-199a inhibits the ability of proliferation and migration by regulating CD44-Ezrin signaling in cutaneous squamous cell carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/25400809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25400809 |
| http://purl.uniprot.org/citations/25400809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25400809 |
| http://purl.uniprot.org/uniprot/#_P15311-mappedCitation-25400809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25400809 |
| http://purl.uniprot.org/uniprot/#_A0A385KNS5-mappedCitation-25400809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25400809 |
| http://purl.uniprot.org/uniprot/#_A0A1Z1VXF2-mappedCitation-25400809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25400809 |
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| http://purl.uniprot.org/uniprot/#_B2R6J2-mappedCitation-25400809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25400809 |
| http://purl.uniprot.org/uniprot/#_B4XHE2-mappedCitation-25400809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25400809 |
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