| http://purl.uniprot.org/citations/2540197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2540197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2540197 | http://www.w3.org/2000/01/rdf-schema#comment | "We report that a cysteine residue in the human beta 2-adrenergic receptor (beta 2AR) is covalently modified by thioesterification with palmitic acid. By site-directed mutagenesis of the receptor, we have identified Cys341 in the carboxyl tail of the protein as the most likely site of palmitoylation. Mutation of Cys341 to glycine results in a nonpalmitoylated form of the receptor that exhibits a drastically reduced ability to mediate isoproterenol stimulation of adenylyl cyclase. The functional impairment of this mutated beta 2AR is also reflected in a markedly reduced ability to form a guanyl nucleotide-sensitive high affinity state for agonists, characteristic of wild-type receptor. These results indicate that post-translational modification by palmitate of beta 2AR may play a crucial role in the normal coupling of the receptor to the adenylyl cyclase signal transduction system."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)83271-9"xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)83271-9"xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/author | "Bouvier M."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/author | "Bouvier M."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/author | "Caron M.G."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/author | "Caron M.G."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/author | "O'Dowd B.F."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/author | "O'Dowd B.F."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/author | "Hnatowich M."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/author | "Hnatowich M."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/pages | "7564-7569"xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/pages | "7564-7569"xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/title | "Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/title | "Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor."xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/volume | "264"xsd:string |
| http://purl.uniprot.org/citations/2540197 | http://purl.uniprot.org/core/volume | "264"xsd:string |