| http://purl.uniprot.org/citations/25404359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25404359 | http://www.w3.org/2000/01/rdf-schema#comment | "Granzyme B (GzmB) plays a major role in CTLs and NK cell-mediated elimination of virus-infected cells and tumors. Human GzmB preferentially induces target cell apoptosis by cleaving the proapoptotic Bcl-2 family member Bid, which, together with Bax, induces mitochondrial outer membrane permeabilization. We previously showed that GzmB also induces a rapid accumulation of the tumor-suppressor protein p53 within target cells, which seems to be involved in GzmB-induced apoptosis. In this article, we show that GzmB-activated p53 accumulates on target cell mitochondria and interacts with Bcl-2. This interaction prevents Bcl-2 inhibitory effect on both Bax and GzmB-truncated Bid, and promotes GzmB-induced mitochondrial outer membrane permeabilization. Consequently, blocking p53-Bcl-2 interaction decreases GzmB-induced Bax activation, cytochrome c release from mitochondria, and subsequent effector caspases activation leading to a decreased sensitivity of target cells to both GzmB and CTL/NK-mediated cell death. Together, our results define p53 as a new important player in the GzmB apoptotic signaling pathway and in CTL/NK-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1401978"xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/author | "Thiery J."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/author | "Mami-Chouaib F."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/author | "Martinvalet D."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/author | "Gros G."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/author | "Favre L."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/author | "Chouaib S."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/author | "Ziani L."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/author | "Ben Safta T."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/author | "Lamendour L."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/pages | "418-428"xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/title | "Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://purl.uniprot.org/core/volume | "194"xsd:string |
| http://purl.uniprot.org/citations/25404359 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25404359 |
| http://purl.uniprot.org/citations/25404359 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25404359 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-25404359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25404359 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-25404359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25404359 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-25404359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25404359 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-25404359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25404359 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-25404359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25404359 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-25404359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25404359 |