| http://purl.uniprot.org/citations/25406362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25406362 | http://www.w3.org/2000/01/rdf-schema#comment | "Fragile X syndrome (FXS) is the most common inherited form of intellectual disability caused by the CGG trinucleotide expansion in the 3'-untranslated region of the FMR1 gene on the X chromosome, that silences the expression of the Fragile X mental retardation protein (FMRP). FMRP has been shown to bind to a G-rich region within the PSD-95 mRNA which encodes for the postsynaptic density protein 95 (PSD-95), and together with the microRNA miR-125a, to play an important role in the reversible inhibition of the PSD-95 mRNA translation in neurons. The loss of FMRP in Fmr1 KO mice disables this translation control in the production of the PSD-95 protein. Interestingly, the miR-125a binding site on PSD-95 mRNA is embedded in the G-rich region bound by FMRP and postulated to adopt one or more G quadruplex structures. In this study, we have used different biophysical techniques to validate and characterize the formation of parallel G quadruplex structures and binding of miR-125a to its complementary sequence located within the 3' UTR of PSD-95 mRNA. Our results indicate that the PSD-95 mRNA G-rich region folds into alternate G quadruplex conformations that coexist in equilibrium. miR-125a forms a stable complex with PSD-95 mRNA, as evident by characteristic Watson-Crick base-pairing that coexists with one of the G quadruplex forms, suggesting a novel mechanism for G quadruplex structures to regulate the access of miR-125a to its binding site."xsd:string |
| http://purl.uniprot.org/citations/25406362 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.046722.114"xsd:string |
| http://purl.uniprot.org/citations/25406362 | http://purl.uniprot.org/core/author | "Stefanovic S."xsd:string |
| http://purl.uniprot.org/citations/25406362 | http://purl.uniprot.org/core/author | "Bassell G.J."xsd:string |
| http://purl.uniprot.org/citations/25406362 | http://purl.uniprot.org/core/author | "Mihailescu M.R."xsd:string |
| http://purl.uniprot.org/citations/25406362 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25406362 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/25406362 | http://purl.uniprot.org/core/pages | "48-60"xsd:string |
| http://purl.uniprot.org/citations/25406362 | http://purl.uniprot.org/core/title | "G quadruplex RNA structures in PSD-95 mRNA: potential regulators of miR-125a seed binding site accessibility."xsd:string |
| http://purl.uniprot.org/citations/25406362 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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