| http://purl.uniprot.org/citations/25410714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25410714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25410714 | http://www.w3.org/2000/01/rdf-schema#comment | "Sleeping sickness is caused by trypanosome parasites, which infect humans and livestock in Sub-Saharan Africa. Haem is an important growth factor for the parasites and is acquired from the host by receptor-mediated uptake of haptoglobin (Hp)-haemoglobin (Hb) complexes. The parasite Hp-Hb receptor (HpHbR) is also a target for a specialized innate immune defence executed by trypanosome-killing lipoprotein particles containing an Hp-related protein in complex with Hb. Here we report the structure of the multimeric complex between human Hp-Hb and Trypanosoma brucei brucei HpHbR. Two receptors forming kinked three-helical rods with small head regions bind to Hp and the β-subunits of Hb (βHb), with one receptor at each end of the dimeric Hp-Hb complex. The Hb β-subunit haem group directly associates with the receptors, which allows for sensing of haem-containing Hp-Hb. The HpHbR-binding region of Hp is conserved in Hp-related protein, indicating an identical recognition of Hp-Hb and trypanolytic particles by HpHbR in human plasma."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms6487"xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms6487"xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/author | "Andersen C.B."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/author | "Andersen C.B."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/author | "Moestrup S.K."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/author | "Moestrup S.K."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/author | "Torvund-Jensen M."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/author | "Torvund-Jensen M."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/author | "Stodkilde K."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/author | "Stodkilde K."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/pages | "5487"xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/pages | "5487"xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/title | "Structural basis for trypanosomal haem acquisition and susceptibility to the host innate immune system."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/title | "Structural basis for trypanosomal haem acquisition and susceptibility to the host innate immune system."xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25410714 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25410714 |
| http://purl.uniprot.org/citations/25410714 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25410714 |