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http://purl.uniprot.org/citations/25416323http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25416323http://www.w3.org/2000/01/rdf-schema#comment"

Background and objectives

The pathophysiology of tension-type headache is not well understood. Increased peripheral levels of pro-inflammatory cytokines may act as mediators of several chronic pain disorders. The aim of the present study was to investigate the peripheral levels of chemokines in patients with tension-type headache.

Methods

This was a cross sectional study evaluating serum levels of chemokines in age and sex-matched tension-type headache patients, ictally and interictally, and control participants. Beck Depression and Anxiety Inventories were recorded. Serum levels of monocyte chemoattractant protein-1, macrophage inflammatory protein 1α, regulated on activation, normal T cell expressed and secreted, eotaxin, eotaxin-2, interleukin-8, interferon gamma induced protein-10 were measured by enzyme-linked immunosorbent assay.

Results

A total of 96 participants (48 tension-type headache, 48 controls) were included. Interleukin-8 levels were significantly increased in patients with tension-type headache when compared to controls (413.8 (123.4-1756.3) and 329 (107.8-955.6), respectively, P = 0.025). Anxiety and depression scores were higher in patients with tension-type headache but interleukin-8 increase in tension-type headache patients persisted after controlling for anxiety and depression symptoms. Patients with headache at the time of assessment had increased monocyte chemoattractant protein-1 levels when compared with patients without headache (2809.3 (1101-6122.2) and 1630.2 (669.3-31056.8), respectively P = 0.026). Patients with episodic and chronic tension-type headache had no significant differences in serum chemokines levels.

Conclusion

Interleukin-8 was increased in tension-type headache and monocyte chemoattractant protein-1 was higher in tension-type headache patients with headache, suggesting that pro-inflammatory mechanisms may participate in tension-type headache pathophysiology."xsd:string
http://purl.uniprot.org/citations/25416323http://purl.org/dc/terms/identifier"doi:10.1177/0333102414559734"xsd:string
http://purl.uniprot.org/citations/25416323http://purl.uniprot.org/core/author"Teixeira A.L."xsd:string
http://purl.uniprot.org/citations/25416323http://purl.uniprot.org/core/author"Duarte H."xsd:string
http://purl.uniprot.org/citations/25416323http://purl.uniprot.org/core/author"Rocha N.P."xsd:string
http://purl.uniprot.org/citations/25416323http://purl.uniprot.org/core/author"Domingues R.B."xsd:string
http://purl.uniprot.org/citations/25416323http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25416323http://purl.uniprot.org/core/name"Cephalalgia"xsd:string
http://purl.uniprot.org/citations/25416323http://purl.uniprot.org/core/pages"801-806"xsd:string
http://purl.uniprot.org/citations/25416323http://purl.uniprot.org/core/title"Increased serum levels of interleukin-8 in patients with tension-type headache."xsd:string
http://purl.uniprot.org/citations/25416323http://purl.uniprot.org/core/volume"35"xsd:string
http://purl.uniprot.org/citations/25416323http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25416323
http://purl.uniprot.org/citations/25416323http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25416323
http://purl.uniprot.org/uniprot/#_A0A7U3S0Q4-mappedCitation-25416323http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25416323
http://purl.uniprot.org/uniprot/#_P10145-mappedCitation-25416323http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25416323
http://purl.uniprot.org/uniprot/A0A7U3S0Q4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25416323
http://purl.uniprot.org/uniprot/P10145http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25416323