| http://purl.uniprot.org/citations/25417162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25417162 | http://www.w3.org/2000/01/rdf-schema#comment | "X chromosome inactivation (XCI) depends on the long noncoding RNA Xist and its recruitment of Polycomb Repressive Complex 2 (PRC2). PRC2 is also targeted to other sites throughout the genome to effect transcriptional repression. Using XCI as a model, we apply an unbiased proteomics approach to isolate Xist and PRC2 regulators and identified ATRX. ATRX unexpectedly functions as a high-affinity RNA-binding protein that directly interacts with RepA/Xist RNA to promote loading of PRC2 in vivo. Without ATRX, PRC2 cannot load onto Xist RNA nor spread in cis along the X chromosome. Moreover, epigenomic profiling reveals that genome-wide targeting of PRC2 depends on ATRX, as loss of ATRX leads to spatial redistribution of PRC2 and derepression of Polycomb responsive genes. Thus, ATRX is a required specificity determinant for PRC2 targeting and function."xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2014.10.019"xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/author | "Jeon Y."xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/author | "White F."xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/author | "Lee J.T."xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/author | "Del Rosario A."xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/author | "Sarma K."xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/author | "Sadreyev R."xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/author | "Cifuentes-Rojas C."xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/author | "Ergun A."xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/pages | "869-883"xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/title | "ATRX directs binding of PRC2 to Xist RNA and Polycomb targets."xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://purl.uniprot.org/core/volume | "159"xsd:string |
| http://purl.uniprot.org/citations/25417162 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25417162 |
| http://purl.uniprot.org/citations/25417162 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25417162 |
| http://purl.uniprot.org/uniprot/#_P09874-mappedCitation-25417162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25417162 |
| http://purl.uniprot.org/uniprot/#_P62805-mappedCitation-25417162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25417162 |
| http://purl.uniprot.org/uniprot/#_Q3UY26-mappedCitation-25417162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25417162 |
| http://purl.uniprot.org/uniprot/#_Q3UZ76-mappedCitation-25417162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25417162 |
| http://purl.uniprot.org/uniprot/#_Q8BSH0-mappedCitation-25417162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25417162 |
| http://purl.uniprot.org/uniprot/#_P46100-mappedCitation-25417162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25417162 |
| http://purl.uniprot.org/uniprot/#_O75367-mappedCitation-25417162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25417162 |