| http://purl.uniprot.org/citations/25427912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25427912 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) modulate exposure levels to ethanol/acetaldehyde. Endoscopic screening of 6,014 Japanese alcoholics yielded high detection rates of esophageal squamous cell carcinoma (SCC; 4.1%) and head and neck SCC (1.0%). The risks of upper aerodigestive tract SCC/dysplasia, especially of multiple SCC/dysplasia, were increased in a multiplicative fashion by the presence of a combination of slow-metabolizing ADH1B*1/*1 and inactive heterozygous ALDH2*1/*2 because of prolonged exposure to higher concentrations of ethanol/acetaldehyde. A questionnaire asking about current and past facial flushing after drinking a glass (≈180 mL) of beer is a reliable tool for detecting the presence of inactive ALDH2. We invented a health-risk appraisal (HRA) model including the flushing questionnaire and drinking, smoking, and dietary habits. Esophageal SCC was detected at a high rate by endoscopic mass-screening in high HRA score persons. A total of 5.0% of 4,879 alcoholics had a history of (4.0%) or newly diagnosed (1.0%) gastric cancer. Their high frequency of a history of gastric cancer is partly explained by gastrectomy being a risk factor for alcoholism because of altered ethanol metabolism, e.g., by blood ethanol level overshooting. The combination of H. pylori-associated atrophic gastritis and ALDH2*1/*2 showed the greatest risk of gastric cancer in alcoholics. High detection rates of advanced colorectal adenoma/carcinoma were found in alcoholics, 15.7% of 744 immunochemical fecal occult blood test (IFOBT)-negative alcoholics and 31.5% of the 393 IFOBT-positive alcoholics. Macrocytosis with an MCV≥106 fl increased the risk of neoplasia in the entire aerodigestive tract of alcoholics, suggesting that poor nutrition as well as ethanol/acetaldehyde exposure plays an important role in neoplasia."xsd:string |
| http://purl.uniprot.org/citations/25427912 | http://purl.org/dc/terms/identifier | "doi:10.1007/978-3-319-09614-8_15"xsd:string |
| http://purl.uniprot.org/citations/25427912 | http://purl.uniprot.org/core/author | "Yokoyama A."xsd:string |
| http://purl.uniprot.org/citations/25427912 | http://purl.uniprot.org/core/author | "Yokoyama T."xsd:string |
| http://purl.uniprot.org/citations/25427912 | http://purl.uniprot.org/core/author | "Mizukami T."xsd:string |
| http://purl.uniprot.org/citations/25427912 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25427912 | http://purl.uniprot.org/core/name | "Adv Exp Med Biol"xsd:string |
| http://purl.uniprot.org/citations/25427912 | http://purl.uniprot.org/core/pages | "265-279"xsd:string |
| http://purl.uniprot.org/citations/25427912 | http://purl.uniprot.org/core/title | "Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers."xsd:string |
| http://purl.uniprot.org/citations/25427912 | http://purl.uniprot.org/core/volume | "815"xsd:string |
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