| http://purl.uniprot.org/citations/25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25431134 | http://www.w3.org/2000/01/rdf-schema#comment | "Parathyroid hormone (PTH) stimulates adenylyl cyclase through type 1 PTH receptors (PTH1R) and potentiates the Ca(2+) signals evoked by carbachol, which stimulates formation of inositol 1,4,5-trisphosphate (IP3). We confirmed that in HEK cells expressing PTH1R, acute stimulation with PTH(1-34) potentiated carbachol-evoked Ca(2+) release. This was mediated by locally delivered cyclic AMP (cAMP), but unaffected by inhibition of protein kinase A (PKA), exchange proteins activated by cAMP, cAMP phosphodiesterases (PDEs) or substantial inhibition of adenylyl cyclase. Sustained stimulation with PTH(1-34) causes internalization of PTH1R-adenylyl cyclase signalling complexes, but the consequences for delivery of cAMP to IP3R within cAMP signalling junctions are unknown. Here, we show that sustained stimulation with PTH(1-34) or with PTH analogues that do not evoke receptor internalization reduced the potentiated Ca(2+) signals and attenuated carbachol-evoked increases in cytosolic IP3. Similar results were obtained after sustained stimulation with NKH477 to directly activate adenylyl cyclase, or with the membrane-permeant analogue of cAMP, 8-Br-cAMP. These responses were independent of PKA and unaffected by substantial inhibition of adenylyl cyclase. During prolonged stimulation with PTH(1-34), hyperactive cAMP signalling junctions, within which cAMP is delivered directly and at saturating concentrations to its targets, mediate sensitization of IP3R and a more slowly developing inhibition of IP3 accumulation."xsd:string |
| http://purl.uniprot.org/citations/25431134 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.163071"xsd:string |
| http://purl.uniprot.org/citations/25431134 | http://purl.uniprot.org/core/author | "Taylor C.W."xsd:string |
| http://purl.uniprot.org/citations/25431134 | http://purl.uniprot.org/core/author | "Tovey S.C."xsd:string |
| http://purl.uniprot.org/citations/25431134 | http://purl.uniprot.org/core/author | "Meena A."xsd:string |
| http://purl.uniprot.org/citations/25431134 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25431134 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/25431134 | http://purl.uniprot.org/core/pages | "408-420"xsd:string |
| http://purl.uniprot.org/citations/25431134 | http://purl.uniprot.org/core/title | "Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions."xsd:string |
| http://purl.uniprot.org/citations/25431134 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/25431134 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25431134 |
| http://purl.uniprot.org/citations/25431134 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25431134 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MSC1-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_B3KVJ0-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_B3KNM3-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_B4DGH1-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_B4DER3-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_B4DJU3-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_B7ZLX9-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_B7ZMI3-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_Q03431-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_Q14643-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_O60266-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |
| http://purl.uniprot.org/uniprot/#_Q0VGD7-mappedCitation-25431134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25431134 |