| http://purl.uniprot.org/citations/25431135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25431135 | http://www.w3.org/2000/01/rdf-schema#comment | "The pentameric WASH complex is best known for its role in regulating receptor trafficking from retromer-rich endosomal subdomains. FAM21 functions to stabilize the WASH complex through its N-terminal head domain and localizes it to endosomes by directly binding the retromer through its extended C-terminal tail. Herein, we used affinity purification combined with mass spectrometry to identify additional FAM21-interacting proteins. Surprisingly, multiple components of the nuclear factor κB (NF-κB) pathway were identified, including the p50 and p65 (RelA) NF-κB subunits. We show that FAM21 interacts with these components and regulates NF-κB-dependent gene transcription at the level of p65 chromatin binding. We further demonstrate that FAM21 contains a functional monopartite nuclear localization signal sequence (NLS) as well as a CRM1/exportin1-dependent nuclear export signal (NES), both of which work jointly with the N-terminal head domain and C-terminal retromer recruitment domain to regulate FAM21 cytosolic and nuclear subcellular localization. Finally, our findings indicate that FAM21 depletion sensitizes pancreatic cancer cells to gemcitabine and 5-fluorouracil. Thus, FAM21 not only functions as an integral component of the cytoplasmic WASH complex, but also modulates NF-κB gene transcription in the nucleus."xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.161513"xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/author | "Zhang J.S."xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/author | "Gomez T.S."xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/author | "Osborne D.G."xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/author | "Phillips-Krawczak C.A."xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/author | "Deng Z.H."xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/pages | "373-384"xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/title | "Nuclear FAM21 participates in NF-kappaB-dependent gene regulation in pancreatic cancer cells."xsd:string |
| http://purl.uniprot.org/citations/25431135 | http://purl.uniprot.org/core/volume | "128"xsd:string |
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