| http://purl.uniprot.org/citations/25443631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25443631 | http://www.w3.org/2000/01/rdf-schema#comment | "Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor (TNF) signaling activation. Mice lacking Sharpin, a critical subunit of LUBAC, spontaneously develop inflammatory lesions in the skin and other organs. Here we show that TNF receptor 1 (TNFR1)-associated death domain (TRADD)-dependent TNFR1 signaling in epidermal keratinocytes drives skin inflammation in Sharpin-deficient mice. Epidermis-restricted ablation of Fas-associated protein with death domain (FADD) combined with receptor-interacting protein kinase 3 (RIPK3) deficiency fully prevented skin inflammation, while single RIPK3 deficiency only delayed and partly ameliorated lesion development in Sharpin-deficient mice, showing that inflammation is primarily driven by TRADD- and FADD-dependent keratinocyte apoptosis while necroptosis plays a minor role. At the cellular level, Sharpin deficiency sensitized primary murine keratinocytes, human keratinocytes, and mouse embryonic fibroblasts to TNF-induced apoptosis. Depletion of FADD or TRADD in Sharpin-deficient HaCaT cells suppressed TNF-induced apoptosis, indicating the importance of FADD and TRADD in Sharpin-dependent anti-apoptosis signaling in keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.03422"xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Kumari S."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Martinez C."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Kuiper J."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Dikic I."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Ikeda F."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Lopez-Mosqueda J."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Pasparakis M."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Shiraishi R."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Romanowska M."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Lutzmayer S."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/author | "Redouane Y."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/title | "Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis."xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/25443631 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25443631 |
| http://purl.uniprot.org/citations/25443631 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25443631 |
| http://purl.uniprot.org/uniprot/#_D3YXL4-mappedCitation-25443631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25443631 |
| http://purl.uniprot.org/uniprot/#_E0CZH2-mappedCitation-25443631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25443631 |
| http://purl.uniprot.org/uniprot/#_E9PZP3-mappedCitation-25443631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25443631 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPT3-mappedCitation-25443631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25443631 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQW9-mappedCitation-25443631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25443631 |