| http://purl.uniprot.org/citations/25447529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25447529 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss of endothelial adherens junctions is involved in tumor metastasis. Here, we demonstrate that, in the metastatic Lu1205 melanoma cells, expression of the CD44 variant CD44v8-v10 induced junction disassembly and vascular endothelial (VE)-cadherin phosphorylation at Y658 and Y731. Short interfering RNA (siRNA)-mediated CD44 knockdown or sialic acid cleavage reversed these effects. Moreover, microspheres coated with recombinant CD44v8-v10 promoted endothelial junction disruption. Overexpression of CD44v8-v10 but not of standard CD44 (CD44s) promoted gap formation in the non-metastatic WM35 melanoma cells, whereas CD44 knockdown or neuraminidase treatment dramatically diminished melanoma transendothelial migration. Endothelial cells transfected with the phosphomimetic VE-cadherin mutant Y658E supported transmigration of CD44-silenced Lu1205 cells. Our findings imply that CD44 variant isoform (CD44v) but not CD44s regulates endothelial junction loss, promoting melanoma extravasation."xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2014.10.027"xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/author | "Bai H."xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/author | "Song Y."xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/author | "Fu C."xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/author | "Song E."xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/pages | "4573-4582"xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/title | "CD44 variant, but not standard CD44 isoforms, mediate disassembly of endothelial VE-cadherin junction on metastatic melanoma cells."xsd:string |
| http://purl.uniprot.org/citations/25447529 | http://purl.uniprot.org/core/volume | "588"xsd:string |
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