| http://purl.uniprot.org/citations/25447820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25447820 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously demonstrated that the expression of HSP20, a small heat shock protein, is inversely correlated with the progression of HCC. Inflammation is associated with HCC, and numerous cytokines, including TNF-α, act as key mediators in the progression of HCC. In the present study, we investigated whether HSP20 is implicated in the TNF-α-stimulated intracellular signaling in HCC using human HCC-derived HuH7 cells in the presence of TNF-α. In HSP20-overexpressing HCC cells, the cell growth was retarded compared with that in the control cells under long-term exposure of TNF-α. Because NF-κB pathway is the main intracellular signaling system activated by TNF-α, we investigated the effects of HSP20-overexpression of this pathway. The protein levels of IKK-α, but not IKK-β, in the HSP20-overexpressing cells were decreased. Short-term exposure to TNF-α-induced phosphorylation and degradation of IκB, and the phosphorylation and transactivational activity of NF-κB were suppressed in the HSP20-overexpressing HCC cells. Furthermore, the increase in IKK-α levels was accompanied by a decrease in the HSP20 levels in human HCC tissues. These findings strongly suggest that HSP20 might decrease the IKK-α protein level and that it down-regulates the TNF-α-stimulated intracellular signaling in HCC, thus resulting in the suppression of HCC progression."xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2014.10.010"xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/author | "Nagasawa T."xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/author | "Toyoda H."xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/author | "Yasuda E."xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/author | "Kumada T."xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/author | "Kozawa O."xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/author | "Matsushima-Nishiwaki R."xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/author | "Matsuura J."xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/author | "Kaneoka Y."xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/name | "Arch Biochem Biophys"xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/pages | "1-8"xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/title | "Heat shock protein 20 (HSPB6) regulates TNF-alpha-induced intracellular signaling pathway in human hepatocellular carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://purl.uniprot.org/core/volume | "565"xsd:string |
| http://purl.uniprot.org/citations/25447820 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25447820 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-25447820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25447820 |
| http://purl.uniprot.org/uniprot/#_A0A384MEB1-mappedCitation-25447820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25447820 |
| http://purl.uniprot.org/uniprot/#_A0A411D318-mappedCitation-25447820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25447820 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X8M9-mappedCitation-25447820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25447820 |
| http://purl.uniprot.org/uniprot/#_A0A510GFL8-mappedCitation-25447820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25447820 |
| http://purl.uniprot.org/uniprot/#_B5BUQ6-mappedCitation-25447820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25447820 |
| http://purl.uniprot.org/uniprot/#_A0A977WMN2-mappedCitation-25447820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25447820 |