| http://purl.uniprot.org/citations/25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25450809 | http://www.w3.org/2000/01/rdf-schema#comment | "IDO1, which encodes the immunosuppressive and tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-1 (IDO1), is a target for interferon-γ (IFN-γ). IDO1-mediated tryptophan catabolism in dendritic cells and macrophages arrests T cell proliferation, thereby providing a molecular basis for the immunosuppressive function of IDO1. Whether the entry of tryptophan into IDO1-expressing cells is also regulated by IFN-γ is not known. Here we used a human colonic epithelial cell line (CCD841) and a mouse dendritic cell line (DC2.4) to test the hypothesis that IFN-γ, which induces IDO1, also induces a tryptophan transporter to promote substrate availability to IDO1. Upon treatment with IFN-γ, there was a marked increase in IDO1 mRNA and a concomitant increase in tryptophan uptake in both cell lines. The induced uptake system was selective for tryptophan and saturable with a Michaelis constant of 36±3 μM in CCD841 cells and 0.5±0.1 μM in DC2.4 cells. The induction by IFN-γ and the tryptophan-selectivity of the induced transport system were demonstrable even in the presence of physiologic concentrations of all other amino acids. Since kynurenine, the catabolic end product of IDO1, is a signaling molecule as an agonist for the aryl hydrocarbon receptor (AhR), we examined if AhR signaling induces the tryptophan-selective transporter. Treatment of the cells with kynurenine and other AhR agonists increased tryptophan uptake. The present studies demonstrate that IFN-γ coordinately induces IDO1 and a tryptophan-selective transporter to maximize tryptophan depletion in IDO1-expressing cells and that the process involves a positive feedback mechanism via kynurenine-AhR signaling."xsd:string |
| http://purl.uniprot.org/citations/25450809 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamem.2014.10.021"xsd:string |
| http://purl.uniprot.org/citations/25450809 | http://purl.uniprot.org/core/author | "Babu E."xsd:string |
| http://purl.uniprot.org/citations/25450809 | http://purl.uniprot.org/core/author | "Ganapathy V."xsd:string |
| http://purl.uniprot.org/citations/25450809 | http://purl.uniprot.org/core/author | "Bhutia Y.D."xsd:string |
| http://purl.uniprot.org/citations/25450809 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25450809 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/25450809 | http://purl.uniprot.org/core/pages | "453-462"xsd:string |
| http://purl.uniprot.org/citations/25450809 | http://purl.uniprot.org/core/title | "Interferon-gamma induces a tryptophan-selective amino acid transporter in human colonic epithelial cells and mouse dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/25450809 | http://purl.uniprot.org/core/volume | "1848"xsd:string |
| http://purl.uniprot.org/citations/25450809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25450809 |
| http://purl.uniprot.org/citations/25450809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25450809 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1L1-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_D3YXV1-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_A0A348GSI3-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_A8YQE4-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_A1Z2M2-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_C4NUL9-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_C4NUM1-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_L0R578-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |
| http://purl.uniprot.org/uniprot/#_Q14609-mappedCitation-25450809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25450809 |