| http://purl.uniprot.org/citations/25452496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25452496 | http://www.w3.org/2000/01/rdf-schema#comment | "Transmembrane guanylyl cyclases (GCs), with activity regulated by peptide ligands and/or calcium-binding proteins, are essential for various physiological and sensory processes. The mode of activation of the GC subtype GC-G, which is expressed in neurons of the Grueneberg ganglion that respond to cool temperatures, has been elusive. In searching for appropriate stimuli to activate GC-G, we found that its enzymatic activity is directly stimulated by cool temperatures. In this context, it was observed that dimerization/oligomerization of GC-G, a process generally considered as critical for enzymatic activity of GCs, is strongly enhanced by coolness. Moreover, heterologous expression of GC-G in cultured cells rendered these cells responsive to coolness; thus, the protein might be a sensor for cool temperatures. This concept is supported by the observation of substantially reduced coolness-induced response of Grueneberg ganglion neurons and coolness-evoked ultrasonic vocalization in GC-G-deficient mouse pups. GC-G may be a novel thermosensory protein with functional implications for the Grueneberg ganglion, a sensory organ responding to cool temperatures."xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201489652"xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/author | "Chao Y.C."xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/author | "Lin Y.C."xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/author | "Chen C.C."xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/author | "Breer H."xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/author | "Yang R.B."xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/author | "Fleischer J."xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/pages | "294-306"xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/title | "Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures."xsd:string |
| http://purl.uniprot.org/citations/25452496 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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