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http://purl.uniprot.org/citations/25460652http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25460652http://www.w3.org/2000/01/rdf-schema#comment"

Background and objective

Lead has long been recognized as a harmful environmental pollutant. People in developing countries like Bangladesh still have a higher risk of lead exposure. Previous research has suggested that the delta-aminolevulinic acid dehydratase (ALAD) genotype can modify lead toxicity and individual susceptibility. As children are more susceptible to lead-induced toxicity, this study investigated whether the ALAD genotype influenced urinary excretion of delta-aminolevulinic acid (U-ALA) among children exposed to environmental lead in Bangladesh.

Methods

Subjects were elementary schoolchildren from a semi-urban industrialized area in Bangladesh. A total of 222 children were studied. Blood and urine were collected to determine ALAD genotypes, blood lead levels and urinary aminolevulinic acid (U-ALA).

Results

The mean BPb level was 9.7 µg/dl for the study children. BPb was significantly positively correlated with hemoglobin (p<0.01). In total, allele frequency for ALAD 1 and 2 was 0.83 and 0.17 respectively. The mean U-ALA concentration was lower in ALAD1-2/2-2 carriers than ALAD1-1 carriers for boys (p=0.001). But for girls, U-ALA did not differ significantly by genotype (p=0.26). When U-ALA was compared by genotype at the same exposure level in a multiple linear regression analysis, boys who were ALAD1-2/2-2 carriers still had a lower level of U-ALA compared to ALAD1-1 carriers.

Conclusion

This study provides information about the influence of ALAD polymorphism and its association with U-ALA in Bangladeshi children. Our results indicate that the ALAD1-2/2-2 genotype may have a protective effect in terms of U-ALA for environmentally lead exposed boys."xsd:string
http://purl.uniprot.org/citations/25460652http://purl.org/dc/terms/identifier"doi:10.1016/j.envres.2014.08.045"xsd:string
http://purl.uniprot.org/citations/25460652http://purl.uniprot.org/core/author"Watanabe C."xsd:string
http://purl.uniprot.org/citations/25460652http://purl.uniprot.org/core/author"Ahmad S.A."xsd:string
http://purl.uniprot.org/citations/25460652http://purl.uniprot.org/core/author"Furusawa H."xsd:string
http://purl.uniprot.org/citations/25460652http://purl.uniprot.org/core/author"Faruquee M.H."xsd:string
http://purl.uniprot.org/citations/25460652http://purl.uniprot.org/core/author"Tasmin S."xsd:string
http://purl.uniprot.org/citations/25460652http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25460652http://purl.uniprot.org/core/name"Environ Res"xsd:string
http://purl.uniprot.org/citations/25460652http://purl.uniprot.org/core/pages"318-323"xsd:string
http://purl.uniprot.org/citations/25460652http://purl.uniprot.org/core/title"Delta-aminolevulinic acid dehydratase (ALAD) polymorphism in lead exposed Bangladeshi children and its effect on urinary aminolevulinic acid (ALA)."xsd:string
http://purl.uniprot.org/citations/25460652http://purl.uniprot.org/core/volume"136"xsd:string
http://purl.uniprot.org/citations/25460652http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25460652
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http://purl.uniprot.org/uniprot/A0A140VJL9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25460652
http://purl.uniprot.org/uniprot/P13716http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25460652
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