| http://purl.uniprot.org/citations/25467979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25467979 | http://www.w3.org/2000/01/rdf-schema#comment | "How the sequential specification of neurons and progressive loss of potency associated with aging neural progenitors are regulated in vertebrate brain development is poorly understood. By examining a temporal differentiation lineage in the hindbrain, we here identify Tgfβ as a switch signal that executes the transition between early and late phases of neurogenesis and concurrently constrains progenitor potency. Young progenitors have inherent competence to produce late-born neurons, but implementation of late-differentiation programs requires suppression of early identity genes achieved through temporally programmed activation of Tgfβ downstream of Shh signaling. Unexpectedly, we find that sequentially occurring fate-switch decisions are temporally coupled, and onset of Tgfβ signaling appears thereby to impact on the overall lifespan of the temporal lineage. Our study establishes Tgfβ as a regulator of temporal identity and potency of neural stem cells, and provides proof of concept that Tgfβ can be applied to modulate temporal specification of neurons in stem cell engineering."xsd:string |
| http://purl.uniprot.org/citations/25467979 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2014.10.033"xsd:string |
| http://purl.uniprot.org/citations/25467979 | http://purl.uniprot.org/core/author | "Dias J.M."xsd:string |
| http://purl.uniprot.org/citations/25467979 | http://purl.uniprot.org/core/author | "Ericson J."xsd:string |
| http://purl.uniprot.org/citations/25467979 | http://purl.uniprot.org/core/author | "Alekseenko Z."xsd:string |
| http://purl.uniprot.org/citations/25467979 | http://purl.uniprot.org/core/author | "Applequist J.M."xsd:string |
| http://purl.uniprot.org/citations/25467979 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25467979 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/25467979 | http://purl.uniprot.org/core/pages | "927-939"xsd:string |
| http://purl.uniprot.org/citations/25467979 | http://purl.uniprot.org/core/title | "Tgfbeta signaling regulates temporal neurogenesis and potency of neural stem cells in the CNS."xsd:string |
| http://purl.uniprot.org/citations/25467979 | http://purl.uniprot.org/core/volume | "84"xsd:string |
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