| http://purl.uniprot.org/citations/25472783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25472783 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-10 is an important immunoregulatory cytokine that mediates its effects via a transmembrane receptor complex consisting of two different chains, IL-10R1 and IL-10R2. While IL-10R2 is ubiquitously expressed and does not bind IL-10 primarily, the expression of IL-10R1 determines cellular responsiveness. However, the current knowledge about the expression and regulation of IL-10R1 is still limited. Here we analyzed the expression of IL-10R1 on monocytic cells and demonstrated that human blood monocytes carried about 720 IL-10-binding sites on their surface. Compared with lymphocytes and various tissue cells and tissues, blood monocytes expressed the highest IL-10R1 levels. The in vitro differentiation of these cells into macrophages provoked a further increase of IL-10R1 surface expression. In contrast, their differentiation into myeloid dendritic cells (mDCs) resulted in reduced surface IL-10R1 levels. The different IL-10R1 levels expressed by monocyte-derived antigen-presenting cell populations were reflected in their different responsiveness toward IL-10. Importantly, also in vivo developed immature macrophages and mDCs showed different IL-10 sensitivity. These data suggest that, compared with monocytes and macrophages, mDCs partially escape from IL-10's inhibitory mechanisms by downregulating IL-10R1."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.org/dc/terms/identifier | "doi:10.1038/gene.2014.69"xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "Kunz S."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "Sterry W."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "Asadullah K."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "Sabat R."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "Volk H.D."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "Wolk K."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "Reineke U."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "Hoflich C."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "Docke W.D."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "von Haehling S."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "Grunberg B.H."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/author | "von Lanzenauer S.H."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/pages | "8-14"xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/title | "Interleukin-10 receptor-1 expression in monocyte-derived antigen-presenting cell populations: dendritic cells partially escape from IL-10's inhibitory mechanisms."xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/25472783 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25472783 |
| http://purl.uniprot.org/citations/25472783 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25472783 |
| http://purl.uniprot.org/uniprot/#_B7ZA31-mappedCitation-25472783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25472783 |
| http://purl.uniprot.org/uniprot/#_B4DVW4-mappedCitation-25472783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25472783 |
| http://purl.uniprot.org/uniprot/#_B3VI66-mappedCitation-25472783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25472783 |