| http://purl.uniprot.org/citations/25477386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25477386 | http://www.w3.org/2000/01/rdf-schema#comment | "It was recently reported that the sizes of many mRNAs change when budding yeast cells exit mitosis and enter the meiotic differentiation pathway. These differences were attributed to length variations of their untranslated regions. The function of UTRs in protein translation is well established. However, the mechanism controlling the expression of distinct transcript isoforms during mitotic growth and meiotic development is unknown. In this study, we order developmentally regulated transcript isoforms according to their expression at specific stages during meiosis and gametogenesis, as compared to vegetative growth and starvation. We employ regulatory motif prediction, in vivo protein-DNA binding assays, genetic analyses and monitoring of epigenetic amino acid modification patterns to identify a novel role for Rpd3 and Ume6, two components of a histone deacetylase complex already known to repress early meiosis-specific genes in dividing cells, in mitotic repression of meiosis-specific transcript isoforms. Our findings classify developmental stage-specific early, middle and late meiotic transcript isoforms, and they point to a novel HDAC-dependent control mechanism for flexible transcript architecture during cell growth and differentiation. Since Rpd3 is highly conserved and ubiquitously expressed in many tissues, our results are likely relevant for development and disease in higher eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gku1185"xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Davis R.W."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Snyder M."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Steinmetz L.M."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Primig M."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Strich R."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Becker E."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Horecka J."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Stuparevic I."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Chu A."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Law M.J."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Kervarrec C."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Lardenois A."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Smagulova F."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Guilleux M.H."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/author | "Waern K."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/pages | "115-128"xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/title | "The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development."xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/25477386 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25477386 |