| http://purl.uniprot.org/citations/25477712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25477712 | http://www.w3.org/2000/01/rdf-schema#comment | "Diethylcarbamazine (DEC), which blocks leukotriene production, abolishes the challenge-induced increase in eosinopoiesis in bone-marrow from ovalbumin-(OVA-) sensitized mice, suggesting that 5-lipoxygenase (5-LO) products contribute to the hematological responses in experimental asthma models. We explored the relationship between 5-LO, central and peripheral eosinophilia, and effectiveness of DEC, using PAS or BALB/c mice and 5-LO-deficient mutants. We quantified eosinophil numbers in freshly harvested or cultured bone-marrow, peritoneal lavage fluid, and spleen, with or without administration of leukotriene generation inhibitors (DEC and MK886) and cisteinyl-leukotriene type I receptor antagonist (montelukast). The increase in eosinophil numbers in bone-marrow, observed in sensitized/challenged wild-type mice, was abolished by MK886 and DEC pretreatment. In ALOX mutants, by contrast, there was no increase in bone-marrow eosinophil counts, nor in eosinophil production in culture, in response to sensitization/challenge. In sensitized/challenged ALOX mice, challenge-induced migration of eosinophils to the peritoneal cavity was significantly reduced relative to the wild-type PAS controls. DEC was ineffective in ALOX mice, as expected from a mechanism of action dependent on 5-LO. In BALB/c mice, challenge significantly increased spleen eosinophil numbers and DEC treatment prevented this increase. Overall, 5-LO appears as indispensable to the systemic hematological response to allergen challenge, as well as to the effectiveness of DEC."xsd:string |
| http://purl.uniprot.org/citations/25477712 | http://purl.org/dc/terms/identifier | "doi:10.1155/2014/403970"xsd:string |
| http://purl.uniprot.org/citations/25477712 | http://purl.uniprot.org/core/author | "Gaspar-Elsas M.I."xsd:string |
| http://purl.uniprot.org/citations/25477712 | http://purl.uniprot.org/core/author | "Xavier-Elsas P."xsd:string |
| http://purl.uniprot.org/citations/25477712 | http://purl.uniprot.org/core/author | "Queto T."xsd:string |
| http://purl.uniprot.org/citations/25477712 | http://purl.uniprot.org/core/author | "Masid-de-Brito D."xsd:string |
| http://purl.uniprot.org/citations/25477712 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25477712 | http://purl.uniprot.org/core/name | "Mediators Inflamm"xsd:string |
| http://purl.uniprot.org/citations/25477712 | http://purl.uniprot.org/core/pages | "403970"xsd:string |
| http://purl.uniprot.org/citations/25477712 | http://purl.uniprot.org/core/title | "Roles of 5-lipoxygenase and cysteinyl-leukotriene type 1 receptors in the hematological response to allergen challenge and its prevention by diethylcarbamazine in a murine model of asthma."xsd:string |
| http://purl.uniprot.org/citations/25477712 | http://purl.uniprot.org/core/volume | "2014"xsd:string |
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