| http://purl.uniprot.org/citations/25484183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25484183 | http://www.w3.org/2000/01/rdf-schema#comment | "Competitive endogenous messenger RNA regulates the transcription of other RNA moleculars through competing for the shared microRNAs. This study was carried out to explore the regulation of AEG-1 messenger RNA as a competitive endogenous RNA in the epithelial-mesenchymal transition and metastasis of lung tumor cells. It is shown that the epithelial-mesenchymal transition was associated with the down-regulation of miR-30a, up-regulation of AEG-1 and mesenchymal markers (Snail and Vimentin); miR-30a inhibited the metastasis of lung tumor A549 cells in vitro, whereas AEG-1 promoted it. These results suggested the potential linkage between miR-30a and genes (AEG-1, Snail and Vimentin) in the epithelial-mesenchymal transition and metastasis of lung tumor cell. It was verified later that the 3'-untranslated regions of AEG-1, Snail and Vimentin bind to miR-30a in A549 cells. Therefore, a competitive endogenous RNAs regulatory network among AEG-1, Snail and Vimentin mediated via competitive binding to miR-30a was proved. That is, the 3'-untranslated region of AEG-1, functioning as the competitive endogenous RNAs, indirectly regulated the expression of Vimentin and Snail in inducing epithelial-mesenchymal transition of human non-small cell lung cancer. In conclusion, our findings demonstrated a competitive endogenous RNAs regulatory network which will help understand the metastasis mechanisms of lung cancer and improve the prevention and treatment of lung cancer."xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejcb.2014.10.006"xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/author | "Guo L."xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/author | "Zhou B."xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/author | "Liu K."xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/author | "Xi T."xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/author | "Yin R."xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/name | "Eur J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/pages | "22-31"xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/title | "AEG-1 3'-untranslated region functions as a ceRNA in inducing epithelial-mesenchymal transition of human non-small cell lung cancer by regulating miR-30a activity."xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/25484183 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25484183 |
| http://purl.uniprot.org/citations/25484183 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25484183 |
| http://purl.uniprot.org/uniprot/#_Q86UE4-mappedCitation-25484183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25484183 |
| http://purl.uniprot.org/uniprot/Q86UE4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25484183 |