| http://purl.uniprot.org/citations/25486571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25486571 | http://www.w3.org/2000/01/rdf-schema#comment | "Stress regulates a panel of important physiological functions and disease states. Epinephrine is produced under stresses threaten to homeostasis. Thioredoxin-1(Trx-1) is a redox regulating protein which is induced to resist stresses and related with various diseases. Thus, it is important to examine whether Trx-1 is induced by epinephrine and to understand the underlying molecular mechanisms that Trx-1 modulates epinephrine stress. Here, we show that the expression of Trx-1 was induced by epinephrine via β-adrenergic receptor/Cyclic AMP/protein kinase A (PKA) signaling pathway in PC12 cells. The down-regulation of Trx-1 by siRNA aggravated accumulation of γ-H2AX and further decreased expression of p53 by epinephrine. Accordingly, Trx-1 overexpression alleviated accumulation of γ-H2AX and restored the expressions of p53 and C/EBP homologous protein (CHOP) in the cortex, hippocampus and thymus of mice. Moreover, Trx-1 overexpression reduced the malondialdehyde concentration by epinephrine. We further explored the mechanism on p53 and γ-H2AX regulated by Trx-1. We found that overexpression of Trx-1 suppressed β-arrestin-1 expression through interaction with β-arrestin-1. Consequently, the downregulation of β-arrestin-1 suppressed the cell viability and the expressions of γ-H2AX and cyclin D1, and increased p53 expression. Taken together, our data suggest that Trx-1/β-arrestin-1 interaction may represent a novel endogenous mechanism on protecting against stress."xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://purl.org/dc/terms/identifier | "doi:10.4161/15384101.2014.949214"xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://purl.uniprot.org/core/author | "Bai J."xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://purl.uniprot.org/core/author | "Jia J.J."xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://purl.uniprot.org/core/author | "Zhou X.S."xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://purl.uniprot.org/core/author | "Zeng X.S."xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25486571 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://purl.uniprot.org/core/pages | "3121-3131"xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://purl.uniprot.org/core/title | "The induction of thioredoxin-1 by epinephrine withdraws stress via interaction with beta-arrestin-1."xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/25486571 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25486571 |
| http://purl.uniprot.org/citations/25486571 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25486571 |
| http://purl.uniprot.org/uniprot/P29066#attribution-C3263C76E4BE03E06D84D3D2A415AFB9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25486571 |
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| http://purl.uniprot.org/uniprot/#_A0A8L2QMJ8-mappedCitation-25486571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25486571 |
| http://purl.uniprot.org/uniprot/#_P29066-mappedCitation-25486571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25486571 |
| http://purl.uniprot.org/uniprot/A0A8I6G7K6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25486571 |
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| http://purl.uniprot.org/uniprot/A0A8I6GL31 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25486571 |
| http://purl.uniprot.org/uniprot/P29066 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25486571 |