| http://purl.uniprot.org/citations/25486926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25486926 | http://www.w3.org/2000/01/rdf-schema#comment | "Several chromosomal rearrangements involving band 3q26 are known to induce EVI1 overexpression. They include inv(3)(q21q26), t(3;3)(q21;q26), t(3;21)(q26;q22) and t(3;12)(q26;p13). Translocations involving the short arm of chromosome 2 and 3q26 have been reported in more than 50 patients with myeloid disorders. However, although the breakpoints on 2p are scattered over a long segment, their distribution had only been analyzed in 9 patients. We performed fluorescent in situ hybridization with a library of BAC (Bacterial Artificial Chromosome) clones in 4 patients with t(2;3)(p15-23;q26). Our results combined with those of the 9 previously reported patients showed scattering of the breakpoints in 2 regions. A 1.08Mb region in band 2p21 encompassing the MTA3, ZFP36L2 and THADA genes was documented in 5 patients. A second region of 1.83Mb in band 2p16.1 was identified in 8 patients. Four patients showed clustering around the BCL11A gene and the remaining 4 around a long intergenic non-coding RNA, FLJ30838. These regions are characterized by the presence of regulatory sequences (CpG islands and promoters) that could be instrumental in EVI1 overexpression."xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bcmd.2014.11.015"xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/author | "Morel F."xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/author | "Tous C."xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/author | "Basinko A."xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/author | "De Braekeleer M."xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/author | "Douet-Guilbert N."xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/author | "Le Bris M.J."xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/author | "Gueganic N."xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/name | "Blood Cells Mol Dis"xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/pages | "160-163"xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/title | "Breakpoint heterogeneity in (2;3)(p15-23;q26) translocations involving EVI1 in myeloid hemopathies."xsd:string |
| http://purl.uniprot.org/citations/25486926 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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