| http://purl.uniprot.org/citations/25487150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25487150 | http://www.w3.org/2000/01/rdf-schema#comment | "The widespread reorganization of cellular architecture in mitosis is achieved through extensive protein phosphorylation, driven by the coordinated activation of a mitotic kinase network and repression of counteracting phosphatases. Phosphatase activity must subsequently be restored to promote mitotic exit. Although Cdc14 phosphatase drives this reversal in budding yeast, protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) activities have each been independently linked to mitotic exit control in other eukaryotes. Here we describe a mitotic phosphatase relay in which PP1 reactivation is required for the reactivation of both PP2A-B55 and PP2A-B56 to coordinate mitotic progression and exit in fission yeast. The staged recruitment of PP1 (the Dis2 isoform) to the regulatory subunits of the PP2A-B55 and PP2A-B56 (B55 also known as Pab1; B56 also known as Par1) holoenzymes sequentially activates each phosphatase. The pathway is blocked in early mitosis because the Cdk1-cyclin B kinase (Cdk1 also known as Cdc2) inhibits PP1 activity, but declining cyclin B levels later in mitosis permit PP1 to auto-reactivate. PP1 first reactivates PP2A-B55; this enables PP2A-B55 in turn to promote the reactivation of PP2A-B56 by dephosphorylating a PP1-docking site in PP2A-B56, thereby promoting the recruitment of PP1. PP1 recruitment to human, mitotic PP2A-B56 holoenzymes and the sequences of these conserved PP1-docking motifs suggest that PP1 regulates PP2A-B55 and PP2A-B56 activities in a variety of signalling contexts throughout eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature14019"xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/author | "Hodgson B."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/author | "Smith D.L."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/author | "Grallert A."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/author | "Hagan I.M."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/author | "Hagting A."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/author | "Pines J."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/author | "Connolly Y."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/author | "Griffiths J.R."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/author | "Boke E."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/pages | "94-98"xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/title | "A PP1-PP2A phosphatase relay controls mitotic progression."xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://purl.uniprot.org/core/volume | "517"xsd:string |
| http://purl.uniprot.org/citations/25487150 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25487150 |
| http://purl.uniprot.org/citations/25487150 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25487150 |
| http://purl.uniprot.org/uniprot/P13681#attribution-9901B5144393BD42AD5BC82F68D372A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25487150 |
| http://purl.uniprot.org/uniprot/P50528#attribution-9901B5144393BD42AD5BC82F68D372A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25487150 |
| http://purl.uniprot.org/uniprot/#_P78759-mappedCitation-25487150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25487150 |
| http://purl.uniprot.org/uniprot/#_Q10428-mappedCitation-25487150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25487150 |
| http://purl.uniprot.org/uniprot/#_P13681-mappedCitation-25487150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25487150 |
| http://purl.uniprot.org/uniprot/#_O59755-mappedCitation-25487150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25487150 |