| http://purl.uniprot.org/citations/25488990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25488990 | http://www.w3.org/2000/01/rdf-schema#comment | "Interactions of B7H1 (programmed death ligand 1 [PD-L1]) with its two ligands, PD-1 and CD80, on T cells play a pivotal role in controlling T cell activation, proliferation, anergy, and apoptosis. However, the interactions between the two pathways remain unknown. Using an alloimmune response model of graft-versus-host disease (GVHD), we report in this study that: 1) Comparison of proliferation and apoptosis of wild-type (WT) and PD-1(-/-)CD4(+) conventional T (Tcon) cells in WT and B7H1(-/-) recipients revealed that B7H1/CD80 interaction per se augments T cell proliferation, and this interaction augments T cell apoptosis mediated by B7H1/PD-1 interaction. This observation was recapitulated in an in vitro MLR assay. 2) Specific blockade of the B7H1/CD80 axis by anti-B7H1 mAb reduces WT-alloreactive Tcon cell proliferation, IL-2 production, expression of PD-1, and apoptosis, resulting in worsening GVHD. In contrast, specific blockade of B7H1/CD80 interaction reduces donor PD-1(-/-) Tcon cell proliferation without an impact on apoptosis, resulting in ameliorating GVHD. 3) B7H1 fused to an Ig Fc domain (B7H1-Ig), when produced in vivo by hydrodynamic injection of B7H1-Ig plasmid, ameliorates GVHD by augmenting proliferation and apoptosis of WT-alloreactive Tcon cells. Conversely, B7H1-Ig treatment has no impact on apoptosis but augments PD-1(-/-) T cell proliferation and worsens GVHD. These results indicate that B7H1/CD80 interaction augments Tcon cell proliferation, IL-2 production, and expression of PD-1, which leads to increased apoptosis mediated by the B7H1/PD-1 pathway. Additionally, by engaging both PD-1 and CD80, B7H1-Ig can be a powerful therapeutic reagent for downregulating the T cell immune response."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1402157"xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/author | "Deng R."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/author | "Yao S."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/author | "Zeng D."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/author | "Racine J."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/author | "Cassady K."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/pages | "560-574"xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/title | "B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease."xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://purl.uniprot.org/core/volume | "194"xsd:string |
| http://purl.uniprot.org/citations/25488990 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25488990 |
| http://purl.uniprot.org/citations/25488990 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25488990 |
| http://purl.uniprot.org/uniprot/#_Q02242-mappedCitation-25488990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25488990 |
| http://purl.uniprot.org/uniprot/#_Q00609-mappedCitation-25488990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25488990 |
| http://purl.uniprot.org/uniprot/#_Q544F3-mappedCitation-25488990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25488990 |
| http://purl.uniprot.org/uniprot/#_Q549R2-mappedCitation-25488990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25488990 |
| http://purl.uniprot.org/uniprot/#_Q3U472-mappedCitation-25488990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25488990 |
| http://purl.uniprot.org/uniprot/#_Q3U4B5-mappedCitation-25488990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25488990 |