| http://purl.uniprot.org/citations/25489064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25489064 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of Wnt signaling results in maladaptive cardiac remodeling and cardiomyopathy. Recently, calcium/calmodulin-dependent protein kinase II (CaMKII) was reported to be a pivotal participant in myocardial remodeling. Because CaMKII was suggested as a downstream target of noncanonical Wnt signaling, we aimed to elucidate the role of CaMKII in dishevelled-1-induced cardiomyopathy and the mechanisms underlying its function. Dishevelled-1-induced cardiomyopathy was reversed by deletion of neither CaMKIIδ nor CaMKIIγ. Therefore, dishevelled-1-transgenic mice were crossed with CaMKIIδγ double-knockout mice. These mice displayed a normal cardiac phenotype without cardiac hypertrophy, fibrosis, apoptosis, or left ventricular dysfunction. Further mechanistic analyses unveiled that CaMKIIδγ couples noncanonical Wnt signaling to histone deacetylase 4 and myosin enhancer factor 2. Therefore, our findings indicate that the axis, consisting of dishevelled-1, CaMKII, histone deacetylase 4, and myosin enhancer factor 2, is an attractive therapeutic target for prevention of cardiac remodeling and its progression to left ventricular dysfunction."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.org/dc/terms/identifier | "doi:10.1161/hypertensionaha.114.04467"xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/author | "Fan J."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/author | "Katus H.A."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/author | "Backs J."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/author | "Kreusser M.M."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/author | "Hardt S.E."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/author | "Hagenmueller M."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/author | "Bernhold E."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/author | "Riffel J.H."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/pages | "335-344"xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/title | "Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy."xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://purl.uniprot.org/core/volume | "65"xsd:string |
| http://purl.uniprot.org/citations/25489064 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25489064 |
| http://purl.uniprot.org/citations/25489064 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25489064 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGS4-mappedCitation-25489064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25489064 |
| http://purl.uniprot.org/uniprot/#_E9Q1T1-mappedCitation-25489064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25489064 |
| http://purl.uniprot.org/uniprot/#_E9Q1W0-mappedCitation-25489064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25489064 |
| http://purl.uniprot.org/uniprot/#_Q3V1X9-mappedCitation-25489064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25489064 |
| http://purl.uniprot.org/uniprot/#_O70459-mappedCitation-25489064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25489064 |
| http://purl.uniprot.org/uniprot/#_Q3TNU8-mappedCitation-25489064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25489064 |