| http://purl.uniprot.org/citations/25490155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25490155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25490155 | http://www.w3.org/2000/01/rdf-schema#comment | "The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) that functions in early autophagy consists of the lipid kinase VPS34, the scaffolding protein VPS15, the tumor suppressor BECN1, and the autophagy-specific subunit ATG14. The structure of the ATG14-containing PI3KC3-C1 was determined by single-particle EM, revealing a V-shaped architecture. All of the ordered domains of VPS34, VPS15, and BECN1 were mapped by MBP tagging. The dynamics of the complex were defined using hydrogen-deuterium exchange, revealing a novel 20-residue ordered region C-terminal to the VPS34 C2 domain. VPS15 organizes the complex and serves as a bridge between VPS34 and the ATG14:BECN1 subcomplex. Dynamic transitions occur in which the lipid kinase domain is ejected from the complex and VPS15 pivots at the base of the V. The N-terminus of BECN1, the target for signaling inputs, resides near the pivot point. These observations provide a framework for understanding the allosteric regulation of lipid kinase activity."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.05115"xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.05115"xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Kim do J."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Kim do J."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Nogales E."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Nogales E."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Hurley J.H."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Hurley J.H."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Baskaran S."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Baskaran S."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Young L.N."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Young L.N."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Stanley R.E."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Stanley R.E."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Carlson L.A."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Carlson L.A."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Grob P."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Grob P."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Stjepanovic G."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/author | "Stjepanovic G."xsd:string |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25490155 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |