| http://purl.uniprot.org/citations/25493333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25493333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25493333 | http://www.w3.org/2000/01/rdf-schema#comment | "The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is ideally suited to capture and present an array of peptide antigens (Ags). In addition, the CD1 family members and MR1 are MHC class I-like molecules that bind lipid-based Ags and vitamin B precursors, respectively. These Ag-bound molecules are subsequently recognized by T cell antigen receptors (TCRs) expressed on the surface of T lymphocytes. Structural and associated functional studies have been highly informative in providing insight into these interactions, which are crucial to immunity, and how they can lead to aberrant T cell reactivity. Investigators have determined over thirty unique TCR-peptide-MHC-I complex structures and twenty unique TCR-peptide-MHC-II complex structures. These investigations have shown a broad consensus in docking geometry and provided insight into MHC restriction. Structural studies on TCR-mediated recognition of lipid and metabolite Ags have been mostly confined to TCRs from innate-like natural killer T cells and mucosal-associated invariant T cells, respectively. These studies revealed clear differences between TCR-lipid-CD1, TCR-metabolite-MR1, and TCR-peptide-MHC recognition. Accordingly, TCRs show remarkable structural and biological versatility in engaging different classes of Ag that are presented by polymorphic and monomorphic Ag-presenting molecules of the immune system."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.org/dc/terms/identifier | "doi:10.1146/annurev-immunol-032414-112334"xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.org/dc/terms/identifier | "doi:10.1146/annurev-immunol-032414-112334"xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "Godfrey D.I."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "Godfrey D.I."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "Turner S.J."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "Turner S.J."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "Miles J.J."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/author | "Miles J.J."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/name | "Annu. Rev. Immunol."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/name | "Annu. Rev. Immunol."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/pages | "169-200"xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/pages | "169-200"xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/title | "T cell antigen receptor recognition of antigen-presenting molecules."xsd:string |
| http://purl.uniprot.org/citations/25493333 | http://purl.uniprot.org/core/title | "T cell antigen receptor recognition of antigen-presenting molecules."xsd:string |