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http://purl.uniprot.org/citations/25495410http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25495410http://www.w3.org/2000/01/rdf-schema#comment"

Aim

Several HLA alleles have been associated with antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) in different populations; however, this has not been investigated in Mexican Mestizos (MM). Thus, the purpose of this preliminary study was to determine the association of HLA class I alleles with AED-induced cADRs in MM patients.

Materials & methods

This case-control association study included 21 MM patients with phenytoin (PHT)-, carbamazepine (CBZ)-, or lamotrigine (LTG)-induced maculopapular exanthema (MPE) or Stevens-Johnson syndrome (SJS); 31 MM patients tolerant to the same AEDs; and 225 unrelated, healthy MM volunteers. HLA class I genotyping was performed. Differences in HLA allele frequencies between AED-induced cADR patients and AED-tolerant patients were assessed. Frequencies of alleles possibly associated with AED-induced cADRs in MM patients were compared with those in MM population.

Results

The frequency of HLA-C*08:01 allele in PHT-induced MPE was higher than that in the PHT-tolerant group (pc=0.0179) or in the MM population (pc<0.0001). For the first time, HLA-A*02:01:01/-B*35:01:01/-C*04:01:01 haplotype was associated with LTG-induced MPE (pc=0.0048 for LTG-tolerant groups and pc<0.0001 for MM population).

Conclusion

Our data suggest the HLA-A*02:01:01/-B*35:01:01/-C*04:01:01 haplotype may be a biomarker for LTG-induced MPE and the HLA-C*08:01 allele for PHT-induced MPE. We also identified HLA-A*01:01:01 and -A*31:01:02 as candidates alleles associated with CBZ-induced MPE in MM patients. However, further investigations are necessary to confirm these findings."xsd:string
http://purl.uniprot.org/citations/25495410http://purl.org/dc/terms/identifier"doi:10.2217/pgs.14.135"xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/author"Martinez-Juarez I.E."xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/author"Monroy-Jaramillo N."xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/author"Falfan-Valencia R."xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/author"Jung-Cook H."xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/author"Alonso-Vilatela M.E."xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/author"Lopez-Lopez M."xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/author"Ortega-Vazquez A."xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/author"Fricke-Galindo I."xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/name"Pharmacogenomics"xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/pages"1881-1891"xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/title"HLA-A*02:01:01/-B*35:01:01/-C*04:01:01 haplotype associated with lamotrigine-induced maculopapular exanthema in Mexican Mestizo patients."xsd:string
http://purl.uniprot.org/citations/25495410http://purl.uniprot.org/core/volume"15"xsd:string
http://purl.uniprot.org/citations/25495410http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25495410
http://purl.uniprot.org/citations/25495410http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25495410
http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-25495410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25495410
http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-25495410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25495410
http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-25495410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25495410
http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-25495410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25495410
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-25495410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25495410
http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-25495410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25495410
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-25495410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25495410
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