| http://purl.uniprot.org/citations/25497092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25497092 | http://www.w3.org/2000/01/rdf-schema#comment | "PGC-1α plays a central role in hepatic gluconeogenesis and has been implicated in the onset of type 2 diabetes. Acetylation is an important posttranslational modification for regulating the transcriptional activity of PGC-1α. Here, we show that PCAF is a pivotal acetyltransferase for acetylating PGC-1α in both fasted and diabetic states. PCAF acetylates two lysine residues K328 and K450 in PGC-1α, which subsequently triggers its proteasomal degradation and suppresses its transcriptional activity. Adenoviral-mediated expression of PCAF in the obese mouse liver greatly represses gluconeogenic enzyme activation and glucose production and improves glucose homeostasis and insulin sensitivity. Moreover, liver-specific knockdown of PCAF stimulates PGC-1α activity, resulting in an increase in blood glucose and hepatic glucose output. Our results suggest that PCAF might be a potential pharmacological target for developing agents against metabolic disorders associated with hyperglycemia, such as obesity and diabetes."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2014.11.029"xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/author | "Ding F."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/author | "Sun C."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/author | "Gu X."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/pages | "2250-2262"xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/title | "PCAF improves glucose homeostasis by suppressing the gluconeogenic activity of PGC-1alpha."xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25497092 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25497092 |
| http://purl.uniprot.org/citations/25497092 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25497092 |
| http://purl.uniprot.org/uniprot/#_B2RR30-mappedCitation-25497092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25497092 |
| http://purl.uniprot.org/uniprot/#_E9Q1F7-mappedCitation-25497092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25497092 |
| http://purl.uniprot.org/uniprot/#_F6SIC5-mappedCitation-25497092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25497092 |
| http://purl.uniprot.org/uniprot/#_F6ZCH1-mappedCitation-25497092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25497092 |
| http://purl.uniprot.org/uniprot/#_Q9JHD1-mappedCitation-25497092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25497092 |