| http://purl.uniprot.org/citations/25497098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25497098 | http://www.w3.org/2000/01/rdf-schema#comment | "In the nematode Caenorhabditis elegans, insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) reduction hyperactivates the transcription factors DAF-16 and heat shock factor 1 (HSF-1), creating long-lived, stress-resistant worms that are protected from proteotoxicity. How DAF-16 executes its distinct functions in response to IIS reduction is largely obscure. Here, we report that NHL-1, a member of the TRIM-NHL protein family, acts in chemosensory neurons to promote stress resistance in distal tissues by DAF-16 activation but is dispensable for the activation of HSF-1. The expression of nhl-1 is regulated by the IIS, defining a neuronal regulatory circuit that controls the organismal stress response. The knockdown of nhl-1 protects nematodes that express the Alzheimer-disease-associated Aβ peptide from proteotoxicity but has no effect on lifespan. Our findings indicate that DAF-16- and HSF-1-regulated heat-responsive mechanisms are differentially controlled by neurons and show that one neuronal protein can be involved in the activation of different stress responses in remote tissues."xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2014.11.028"xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/author | "Moll L."xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/author | "Maman M."xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/author | "Bejerano-Sagie M."xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/author | "Cohen E."xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/author | "Volovik Y."xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/author | "Marques F.C."xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/pages | "2192-2205"xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/title | "Differential regulation of the heat shock factor 1 and DAF-16 by neuronal nhl-1 in the nematode C. elegans."xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25497098 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25497098 |
| http://purl.uniprot.org/citations/25497098 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25497098 |
| http://purl.uniprot.org/uniprot/#_A0A131MCD3-mappedCitation-25497098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25497098 |
| http://purl.uniprot.org/uniprot/#_Q03601-mappedCitation-25497098 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25497098 |
| http://purl.uniprot.org/uniprot/Q03601 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25497098 |
| http://purl.uniprot.org/uniprot/A0A131MCD3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25497098 |