| http://purl.uniprot.org/citations/25499223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25499223 | http://www.w3.org/2000/01/rdf-schema#comment | "B-RafV600E oncogene mutation occurs most commonly in papillary thyroid carcinoma (PTC) and is associated with tumor initiation. However, a genetic modification by B-RafV600E in thyrocytes results in oncogene-induced senescence (OIS). In the present study, we explored the factors involved in the senescence overcome program in PTC. First of all, we observed down-regulation of p-extracellular signal-regulated kinases 1/2 and up-regulation of dual specific phosphatase 6 (DUSP6) in the PTC with B-RafV600E mutation. DUSP6 overexpression in vitro induced extracellular signal-regulated kinases 1/2 dephosphorylation and inhibited B-RafV600E-induced senescence in thyrocytes. Although DUSP6 protein was degraded by B-RafV600E-induced reactive oxygen species (ROS), thyroid-stimulating hormone (TSH) stabilized DUSP6 protein by increasing Mn superoxide dismutase expression and inhibited B-RafV600E-induced senescence. Although serum TSH was not increased, its receptor was markedly upregulated in PTC with B-RafV600E. Furthermore, TSH together with DUSP6 reactivated Ras signaling, resulted in activation of Ras/AKT/glycogen synthase kinase 3β, and stabilized c-Myc protein by inhibiting its degradation. These observations led us to conclude that increased TSH signaling overcomes OIS and is essential for B-RafV600E-induced papillary thyroid carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neo.2014.10.005"xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/author | "Han J.H."xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/author | "Park T.J."xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/author | "Choi Y.W."xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/author | "Soh E.Y."xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/name | "Neoplasia"xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/pages | "1107-1120"xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/title | "TSH signaling overcomes B-RafV600E-induced senescence in papillary thyroid carcinogenesis through regulation of DUSP6."xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/25499223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25499223 |
| http://purl.uniprot.org/citations/25499223 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25499223 |
| http://purl.uniprot.org/uniprot/#_B5BU29-mappedCitation-25499223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25499223 |
| http://purl.uniprot.org/uniprot/#_Q53GP9-mappedCitation-25499223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25499223 |
| http://purl.uniprot.org/uniprot/#_P15056-mappedCitation-25499223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25499223 |
| http://purl.uniprot.org/uniprot/#_Q16828-mappedCitation-25499223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25499223 |
| http://purl.uniprot.org/uniprot/#_Q689E8-mappedCitation-25499223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25499223 |
| http://purl.uniprot.org/uniprot/B5BU29 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25499223 |
| http://purl.uniprot.org/uniprot/Q689E8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25499223 |