| http://purl.uniprot.org/citations/25501240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25501240 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined patients of Han nationality diagnosed with irritable bowel syndrome with diarrhea (IBS-D) in Guangdong, China, to analyze the correlation between DQB1 allele polymorphisms and the genetic susceptibility to IBS-D. A total of 120 IBS-D patients of Han nationality in Guangdong, China, and 60 healthy control volunteers were included. DQB1 allele polymorphisms were investigated by polymerase chain reaction. Subjects' serum interleukin (IL)-10 level, colonic permeability, and tight junction marker zonula occludens 1 (ZO1) mRNA level were also investigated. Our data showed that the DQB1*02 allele frequency was significantly higher in IBS-D patients, while the DQB1*0603 frequency was lower than in healthy volunteers. The DQB1*03, DQB1*04, DQB1*05, DQB1*0601, DQB1*0602, and DQB1*0604 alleles did not show significant differences between IBS-D patients and healthy controls. Furthermore, patients with DQB1*03-positive and DQB1*0603-negative alleles showed more severe colonic permeability and lower serum IL-10 level and ZO1 level compared to healthy controls or even IBS-D patients with other genotypes. The present study indicated the DQB1*02 or DQB1*0603 alleles are related to IBS-D occurrence in Guangdong, China, and the mechanism of the disease may be related to reduced serum IL-10 levels."xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.org/dc/terms/identifier | "doi:10.4238/2014.december.4.23"xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/author | "Xie X."xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/author | "Zheng C."xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/author | "Yu F."xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/author | "Luo Q."xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/author | "Zhou F."xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/name | "Genet Mol Res"xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/pages | "10285-10293"xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/title | "Correlation between DQB1 genetic polymorphism and genetic susceptibility in patients diagnosed with irritable bowel syndrome with diarrhea."xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/25501240 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25501240 |
| http://purl.uniprot.org/citations/25501240 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25501240 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-25501240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501240 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-25501240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501240 |
| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-25501240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501240 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-25501240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501240 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-25501240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501240 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAC7-mappedCitation-25501240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501240 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAE0-mappedCitation-25501240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501240 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAE6-mappedCitation-25501240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501240 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCZ4-mappedCitation-25501240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501240 |